Title:
POLYNUCLEOTIDE AND POLYPEPTIDE SEQUENCES OF HUMAN DENDRITIC CELL IMMUNORECEPTORS
Document Type and Number:
WIPO Patent Application WO2002032958
Kind Code:
A3
Abstract:
Reagents which regulate human dendritic cell immunoreceptor and reagents which bind to human dendritic cell immunoreceptor gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, cancer, asthma, obesity, diabetes, CNS disorders, and cardiovascular disorders.
Inventors:
SMOLYAR ALEX (US)
Application Number:
PCT/EP2001/011812
Publication Date:
February 13, 2003
Filing Date:
October 12, 2001
Export Citation:
Assignee:
BAYER AG (DE)
SMOLYAR ALEX (US)
SMOLYAR ALEX (US)
International Classes:
G01N33/50; A61K38/00; A61K39/395; A61K45/00; A61K48/00; A61P3/00; A61P3/04; A61P3/06; A61P3/10; A61P7/02; A61P9/00; A61P9/14; A61P11/00; A61P11/06; A61P25/00; A61P25/02; A61P25/14; A61P25/16; A61P25/28; A61P35/00; A61P35/04; A61P37/02; A61P37/08; A61P43/00; C07K14/705; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/06; C12N5/08; C12N5/10; C12N9/64; C12N15/09; C12N15/12; C12P21/02; C12Q1/02; C12Q1/68; G01N33/15; G01N33/53; G01N33/566; A61K39/00; (IPC1-7): C07K14/705; C12N15/12; C12N5/10; C12Q1/68; G01N33/50; G01N33/53; A61K48/00; C12N15/62
Other References:
DATABASE EMBL [online] 17 March 1998 (1998-03-17), NCI-CGAP: "ak43b01.s1 Soares_testis_NHT Homo sapiens cDNA clone IMAGE:1408681 3' similar to SW:LECH_CHICK P02707 HEPATIC LECTIN. ;, mRNA sequence.", XP002208843, Database accession no. AA868502
BATES E. ET AL.: "APCs Express DCIR, a Novel C-type Lectin Surface Receptor Containing an Immunoreceptor Tyrosine-Based Inhibitory Motif", THE JOURNAL OF IMMUNOLOGY, THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS, vol. 163, no. 4, 15 August 1999 (1999-08-15), US, pages 1973 - 1983, XP002208840
COLONNA M ET AL.: "Molecular characterization of two novel C-type lectin-like receptors, one of which is selectively expressed in human dendritic cells", EUROPEAN JOURNAL OF IMMUNOLOGY (WILEY-VCH VERLAG GMBH), vol. 30, no. 2, February 2000 (2000-02-01), Weinheim, Deutschland, pages 697 - 704, XP002208841
DATABASE EMBL [online] 1 September 1999 (1999-09-01), BATES E. ET AL.: "Homo sapiens mRNA for dendritic cell immunoreceptor", XP002208844, Database accession no. AJ133532
DRICKAMER KURT: "C-type lectin-like domains", CURRENT OPINION IN STRUCTURAL BIOLOGY, CURRENT BIOLOGY LTD., LONDON, GB, vol. 9, no. 5, October 1999 (1999-10-01), pages 585 - 590, XP002175480, ISSN: 0959-440X
ARCE I. ET AL.: "Molecular and genomic characterization of human DLEC, a novel member of the C-type lectin receptor gene family preferentially expressed on monocyte-derived dendritic cells", EUROPEAN JOURNAL OF IMMUNOLOGY (WILEY-VCH VERLAG GMBH, vol. 31, 30 August 2001 (2001-08-30), Weinheim, Deutschland, pages 2733 - 2740, XP002208842
DATABASE EMBL [online] 6 August 2001 (2001-08-06), SCHMITZ J. ET AL.: "Nucleotide sequence of BDCA-2 antigen", XP002208845, Database accession no. AAF90241
DATABASE EMBL [online] 18 December 2001 (2001-12-18), WERNER G. ET AL.: "Dendritic cell (DC) DCLEC gene", XP002208846, Database accession no. AAD19729
BATES E. ET AL.: "APCs Express DCIR, a Novel C-type Lectin Surface Receptor Containing an Immunoreceptor Tyrosine-Based Inhibitory Motif", THE JOURNAL OF IMMUNOLOGY, THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS, vol. 163, no. 4, 15 August 1999 (1999-08-15), US, pages 1973 - 1983, XP002208840
COLONNA M ET AL.: "Molecular characterization of two novel C-type lectin-like receptors, one of which is selectively expressed in human dendritic cells", EUROPEAN JOURNAL OF IMMUNOLOGY (WILEY-VCH VERLAG GMBH), vol. 30, no. 2, February 2000 (2000-02-01), Weinheim, Deutschland, pages 697 - 704, XP002208841
DATABASE EMBL [online] 1 September 1999 (1999-09-01), BATES E. ET AL.: "Homo sapiens mRNA for dendritic cell immunoreceptor", XP002208844, Database accession no. AJ133532
DRICKAMER KURT: "C-type lectin-like domains", CURRENT OPINION IN STRUCTURAL BIOLOGY, CURRENT BIOLOGY LTD., LONDON, GB, vol. 9, no. 5, October 1999 (1999-10-01), pages 585 - 590, XP002175480, ISSN: 0959-440X
ARCE I. ET AL.: "Molecular and genomic characterization of human DLEC, a novel member of the C-type lectin receptor gene family preferentially expressed on monocyte-derived dendritic cells", EUROPEAN JOURNAL OF IMMUNOLOGY (WILEY-VCH VERLAG GMBH, vol. 31, 30 August 2001 (2001-08-30), Weinheim, Deutschland, pages 2733 - 2740, XP002208842
DATABASE EMBL [online] 6 August 2001 (2001-08-06), SCHMITZ J. ET AL.: "Nucleotide sequence of BDCA-2 antigen", XP002208845, Database accession no. AAF90241
DATABASE EMBL [online] 18 December 2001 (2001-12-18), WERNER G. ET AL.: "Dendritic cell (DC) DCLEC gene", XP002208846, Database accession no. AAD19729
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