Title:
POLYNUCLEOTIDES ENCODING IMMUNOSTIMULATORY FUSION MOLECULES AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/010222
Kind Code:
A3
Abstract:
Polynucleotides encoding immunostimulatory fusion molecules that include an immune cell targeting moiety and a cytokine molecule, pharmaceutical and formulations thereof, and methods of using and making the same, are disclosed.
Inventors:
ANDRESEN THOMAS L (US)
JONES DOUGLAS S (US)
JONES DOUGLAS S (US)
Application Number:
PCT/US2018/040783
Publication Date:
March 07, 2019
Filing Date:
July 03, 2018
Export Citation:
Assignee:
TORQUE THERAPEUTICS INC (US)
International Classes:
C07K14/54; A61K39/395; C07K14/55; C07K16/28; C07K19/00; C12N5/078; C12N5/0783; C12N5/09
Foreign References:
| US20140294708A1 | 2014-10-02 | |||
| US20090257991A1 | 2009-10-15 | |||
| US20130203116A1 | 2013-08-08 | |||
| US20030175270A1 | 2003-09-18 | |||
| US20170080104A1 | 2017-03-23 |
Other References:
HOMBACH ET AL.: "Targeting two co-operating cytokines efficiently shapes immune responses", ONCOIMMUNOLOGY, vol. 2, no. 3, 1 March 2013 (2013-03-01), pages e23205, XP0055582106
YOUNG ET AL.: "Antibody-cytokine fusion proteins for treatment of cancer: engineering cytokines for improved efficacy and safety", SEMIN ONCOL, vol. 41, no. 5, October 2014 (2014-10-01), pages 623 - 636, XP009506872, DOI: doi:10.1053/j.seminoncol.2014.08.002
YOUNG ET AL.: "Antibody-cytokine fusion proteins for treatment of cancer: engineering cytokines for improved efficacy and safety", SEMIN ONCOL, vol. 41, no. 5, October 2014 (2014-10-01), pages 623 - 636, XP009506872, DOI: doi:10.1053/j.seminoncol.2014.08.002
Attorney, Agent or Firm:
XIE, Fang (US)
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