Title:
POLYOL-MODIFIED LIPID COMPOUND AND PREPARATION METHOD AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/001286
Kind Code:
A1
Abstract:
Provided are a polyol-modified lipid compound, a preparation method therefor and an application thereof. The lipid compound and lipid nanoparticles prepared therefrom can target and effectively deliver biologically active substances to target cells and sites, and efficiently achieve pharmacological effects of the biologically active substances. In addition, the lipid compound has a singular molecular weight, which is beneficial for controlling differences between batches, improving the stability of finished drugs, and reducing immunogenicity; it is expected to be used for the development and application of related drugs.
Inventors:
WANG QINGBIN (CN)
HU SHUZHEN (CN)
HAO JING (CN)
ZHANG BAITAO (CN)
ZHU CHANGYOU (CN)
GUO JUN (CN)
ZHAO XUAN (CN)
HU SHUZHEN (CN)
HAO JING (CN)
ZHANG BAITAO (CN)
ZHU CHANGYOU (CN)
GUO JUN (CN)
ZHAO XUAN (CN)
Application Number:
PCT/CN2022/107381
Publication Date:
January 26, 2023
Filing Date:
July 22, 2022
Export Citation:
Assignee:
JENKEM TECH CO LTD TIANJIN (CN)
International Classes:
C07C235/06; A61K9/127; A61K31/08; A61K47/18
Domestic Patent References:
| WO2019089828A1 | 2019-05-09 | |||
| WO2018081480A1 | 2018-05-03 | |||
| WO2021030701A1 | 2021-02-18 |
Foreign References:
| CN114276535A | 2022-04-05 | |||
| CN113402405A | 2021-09-17 | |||
| CN1882693A | 2006-12-20 | |||
| CN106795096A | 2017-05-31 | |||
| CN110352071A | 2019-10-18 | |||
| CN110167922A | 2019-08-23 | |||
| CN110352071A | 2019-10-18 | |||
| CN1882693A | 2006-12-20 | |||
| CN202010229195A | 2020-03-27 |
Attorney, Agent or Firm:
BEIJING LINKTEC IP LAW FIRM (SPECIAL GENERAL PARTNERSHIP) (CN)
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