POLYOXYETHYLENE DERIVATIVE HAVING A PLURALITY OF HYDROXYL GROUPS AT END

Title:

POLYOXYETHYLENE DERIVATIVE HAVING A PLURALITY OF HYDROXYL GROUPS AT END

Document Type and Number:

WIPO Patent Application WO/2012/133490

Kind Code:

A1

Abstract:

Provided is a novel polyoxyethylene derivative which has a plurality of hydroxyl groups at an end. Specifically provided is a polyoxyethylene derivative having a plurality of hydroxyl groups at an end, which can be effectively used for the purpose of modifying a biological material and is able to be industrially produced. This polyoxyethylene derivative is represented by formula (1). (In the formula, the total molecular weight of the polyoxyethylene derivative is 500-160,000; n represents a number of 5-3,650; each of L1, L2 and L3 independently represents an alkylene group, a phenylene group, an ester bond, an amide bond, an ether bond, a urethane bond, a carbonate bond, a secondary amino group or a secondary amino bond; X represents a functional group which is reactive with a biological material; Y represents a hydrophilic group having a plurality of hydroxyl groups each of which is composed of a residue of xylitol or volemitol or a residue of a polyglycerol that is a trimer to 31-mer; Z represents a residue of a compound having 2-5 active hydrogen groups; b and c satisfy 1 ≤ b ≤ 4, 1 ≤ c ≤ 4 and 2 ≤ b + c ≤ 5; and each of d and e independently represents 0 or 1.)

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Inventors:

YOSHIOKA HIROKI
MATANI TAKASHI
YAMAMOTO YUJI

Application Number:

PCT/JP2012/058069

Publication Date:

October 04, 2012

Filing Date:

March 28, 2012

Export Citation:

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Assignee:

NOF CORP (JP)
YOSHIOKA HIROKI
MATANI TAKASHI
YAMAMOTO YUJI

International Classes:

C08G65/329

Domestic Patent References:

WO2008105514A1	2008-09-04
WO2010114074A1	2010-10-07
WO2006028129A1	2006-03-16
WO2008096904A1	2008-08-14
WO2005037911A2	2005-04-28

Foreign References:

JP2010235450A	2010-10-21
JP2008188557A	2008-08-21
JP2010254978A	2010-11-11
JP2006510601A	2006-03-30
JP2007031554A	2007-02-08
JP2008188557A	2008-08-21
JP2004197077A	2004-07-15

Other References:

T. ISHIDA; H. KIWADA ET AL., J. CONTROL. RELEASE, vol. 122, 2007, pages 349 - 355
W. JIS KOOT; R.M.F. VAN SCHIE ET AL., PHARMACEUTICAL RESEARCH, vol. 26, no. 6, 2009, pages 1303 - 1314
THEODORA W. GREENE, PROTECTIVE GROUPS IN ORGANIC SYNTHESIS

Attorney, Agent or Firm:

Shin-Ei Patent Firm, P.C. (7-13 Nishi-Shimbashi 1-chome, Minato-k, Tokyo 03, JP)

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