Title:
POLYPEPTIDE AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/037187
Kind Code:
A1
Abstract:
Provided are a polypeptide and application thereof. The polypeptide comprises a peptide fragment composed of 16-23 consecutive amino acids in an amino acid sequence represented by SEQ ID NO:1. The polypeptide can mitigate metabolic syndrome, achieve weight loss, and treat nonalcoholic fatty liver diseases and cardiovascular diseases.
Inventors:
DONG FUMIN (CA)
Application Number:
PCT/CN2020/112007
Publication Date:
March 04, 2021
Filing Date:
August 28, 2020
Export Citation:
Assignee:
HDL SOLUTIONS OTTAWA (CA)
YANG YU (CN)
YANG YU (CN)
International Classes:
C07K14/00; A61K38/16; A61P1/16
Domestic Patent References:
| WO2008115303A2 | 2008-09-25 |
Foreign References:
| CN109200273A | 2019-01-15 |
Other References:
YING RU, YONG YUAN, YA-FEI QIN, LI FENG, DI TIAN, GUO ZHI-GANG, LI MING-XING: "Protective Effect and Mechanism of Apolipoprotein A-1 Mimetic Peptide L-4F on Atherosclerosis in Mice Model", ZHONGGUO XUNHUAN ZAZHI -CHINESE CIRCULATION JOURNAL, FUWAI YIYUAN, CN, vol. 28, no. 5, 1 January 2013 (2013-01-01), CN, pages 379 - 383, XP055786974, ISSN: 1000-3614, DOI: 10.3969/j.issn.1000-3614.2013.05.017
AZHAR SALMAN, BITTNER STEFANIE, HU JIE, SHEN WEN-JUN, CORTEZ YUAN, HAO XIAO, HAN LU, LAGERSTEDT JENS O., KRAEMER FREDRIC B., JOHAN: "Novel ABCA1 peptide agonists with antidiabetic action", MOLECULAR AND CELLULAR ENDOCRINOLOGY., ELSEVIER IRELAND LTD, IE, vol. 480, 1 January 2019 (2019-01-01), IE, pages 1 - 11, XP055786917, ISSN: 0303-7207, DOI: 10.1016/j.mce.2018.09.011
TANGIRALA RK ET AL., CIRCULATION, vol. 100, 1999, pages 1816 - 1822
AZHAR SALMAN, BITTNER STEFANIE, HU JIE, SHEN WEN-JUN, CORTEZ YUAN, HAO XIAO, HAN LU, LAGERSTEDT JENS O., KRAEMER FREDRIC B., JOHAN: "Novel ABCA1 peptide agonists with antidiabetic action", MOLECULAR AND CELLULAR ENDOCRINOLOGY., ELSEVIER IRELAND LTD, IE, vol. 480, 1 January 2019 (2019-01-01), IE, pages 1 - 11, XP055786917, ISSN: 0303-7207, DOI: 10.1016/j.mce.2018.09.011
TANGIRALA RK ET AL., CIRCULATION, vol. 100, 1999, pages 1816 - 1822
Attorney, Agent or Firm:
KINGSOUND & PARTNERS (CN)
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