Title:
POLYPEPTIDE FRAGMENT B AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/166999
Kind Code:
A1
Abstract:
The present invention relates to the technical field of biomedicine, and specifically relates to a polypeptide fragment B and an application thereof, the polypeptide fragment B having the amino acid sequence shown in SEQ ID NO. 1, wherein the amino acid Xaa at position 10 is Arg, Phe, Glu or Thr, or is not present, the amino acid Xaa at position 16 is Asn, Val, Leu or Gly, or is not present, and the amino acid Xaa at position 25 is Ser, Glu, Met or Arg, or is not present. MP-B significantly improves the colon pathological morphology of an IBD mouse model, reduces colon histopathological scores and colon interferon-gamma expression amounts, and has the ability to interfere with the occurrence of inflammatory bowel disease in mice.
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Inventors:
ZHANG CAIHUA (CN)
CHANG YING (CN)
CHANG YING (CN)
Application Number:
PCT/CN2022/080880
Publication Date:
August 11, 2022
Filing Date:
March 15, 2022
Export Citation:
Assignee:
SHANGHAI LONGXIN BIOMEDICAL TECH CO LTD (CN)
International Classes:
C07K14/335; A23L33/18; A61K38/16; A61P1/00
Foreign References:
| CN112851774A | 2021-05-28 | |||
| CN103044532A | 2013-04-17 |
Attorney, Agent or Firm:
CHANGZHOU BAIYETENGFEI PATENT AGENCY (GENERAL PARTNERSHIP) (CN)
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