Title:
A POLYPEPTIDE HAVING AMIDOLYTIC ACTIVITY FOR A SERPIN
Document Type and Number:
WIPO Patent Application WO2000063394
Kind Code:
A3
Abstract:
An isolated oral bacterial polypeptide having amidolytic activity for cleavage of denatured polypeptides and nondenatured serpin polypeptides and particularly a human alpha 1-proteinase inhibitor polypeptide is provided. The mature polypeptide of the invention has a molecular weight of about 70 kD to about 80 kD. Also provided is an isolated nucleic acid sequence encoding the oral bacterial polypeptide of the invention, methods for identifying inhibitors of the polypeptide and compositions such as immunogenic compositions and inhibitor compositions.
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Inventors:
TRAVIS JAMES (US)
POTEMPA JAN (US)
NELSON DANIEL (US)
POTEMPA JAN (US)
NELSON DANIEL (US)
Application Number:
PCT/US2000/010574
Publication Date:
February 22, 2001
Filing Date:
April 20, 2000
Export Citation:
Assignee:
UNIV GEORGIA RES FOUND (US)
TRAVIS JAMES (US)
POTEMPA JAN (US)
NELSON DANIEL (US)
TRAVIS JAMES (US)
POTEMPA JAN (US)
NELSON DANIEL (US)
International Classes:
C12N9/64; C12N15/57; A61K39/00; (IPC1-7): C12N15/57; C12N9/64; C12Q1/37; A61K39/02
Domestic Patent References:
| WO1999029870A1 | 1999-06-17 |
Other References:
POTEMPA J ET AL: "THE INACTIVATION OF HUMAN PLASMA ALPHA-1 PROTEINASE INHIBITOR BY PROTEINASES FROM STAPHYLOCOCCUS-AUREUS", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 261, no. 30, 1986, pages 14330 - 14334, XP002154472, ISSN: 0021-9258
NELSON DANIEL ET AL: "Inactivation of alpha1-proteinase inhibitor as a broad screen for detecting proteolytic activities in unknown samples.", ANALYTICAL BIOCHEMISTRY, vol. 260, no. 2, 1 July 1998 (1998-07-01), pages 230 - 236, XP002154473, ISSN: 0003-2697
S BUDAVARI ET AL: "The Merck Index", 1996, MERCK & CO, WHITEHOUSE STATION, XP002154475
NELSON DANIEL ET AL: "Purification and characterization of a novel cysteine proteinase (periodontain) from Porphyromonas gingivalis: Evidence for a role in the inactivation of human alpha1-proteinase inhibitor.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 18, 30 April 1999 (1999-04-30), pages 12245 - 12251, XP002154474, ISSN: 0021-9258
NELSON DANIEL ET AL: "Inactivation of alpha1-proteinase inhibitor as a broad screen for detecting proteolytic activities in unknown samples.", ANALYTICAL BIOCHEMISTRY, vol. 260, no. 2, 1 July 1998 (1998-07-01), pages 230 - 236, XP002154473, ISSN: 0003-2697
S BUDAVARI ET AL: "The Merck Index", 1996, MERCK & CO, WHITEHOUSE STATION, XP002154475
NELSON DANIEL ET AL: "Purification and characterization of a novel cysteine proteinase (periodontain) from Porphyromonas gingivalis: Evidence for a role in the inactivation of human alpha1-proteinase inhibitor.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 18, 30 April 1999 (1999-04-30), pages 12245 - 12251, XP002154474, ISSN: 0021-9258
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