Title:
POLYPEPTIDE HAVING EFFECT OF INHIBITING PROLIFERATION OF LEUKEMIA CELLS
Document Type and Number:
WIPO Patent Application WO/2020/147176
Kind Code:
A1
Abstract:
Disclosed is a polypeptide having an effect of inhibiting the proliferation of leukemia cells, and the present invention specifically relates to the use of a polypeptide in a drug for treating leukemia. The polypeptide consists of 37 amino acids, with the amino acid sequence thereof being Lys-Glu-Ser-Met-Asp-Ala-Asn-Lys-Pro-Thr-Lys-Asn-Leu-Pro-Leu-Lys-Lys-Ile-Pro-Cys-Lys-Thr-Ser-Ala-Pro-Ser-Gln-Ser-Phe-Phe-Ala-Arg-Asp-Asn-Thr-Ala-Asn, and the N-terminus of the polypeptide being connected with myristic acid. The polypeptide prepared by the present invention can enter the leukemia cells by connecting with the myristic acid, thereby achieving the effect of inhibiting the proliferation of the leukemia cells.
Inventors:
ZHU JIANG (CN)
ZHONG AN (CN)
LV MEIQI (CN)
ZHONG AN (CN)
LV MEIQI (CN)
Application Number:
PCT/CN2019/077271
Publication Date:
July 23, 2020
Filing Date:
March 07, 2019
Export Citation:
Assignee:
NANJING FENGRUI BIOTECHNOLOGY CO LTD (CN)
International Classes:
C07K14/47; A61K38/17; A61P35/02; C07K1/04; C07K1/06; C07K1/16
Domestic Patent References:
| WO2008021290A2 | 2008-02-21 |
Attorney, Agent or Firm:
NANJING XIANKE PATENT AGENCY LAW FIRM (ORDINARY PARTNERSHIP) (CN)
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