Title:
POLYPEPTIDE FOR INHIBITING INTRACELLULAR LIPID ACCUMULATION, AND SYNTHESIS METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2022/184165
Kind Code:
A1
Abstract:
Provided in the present invention are a polypeptide for inhibiting intracellular lipid accumulation and a synthesis method therefor. The polypeptide has a relatively high target affinity and reduces the activity of sterol O-acyltransferase by means of inhibiting binding of lectin and sterol O-acyltransferase. The polypeptide has a simple synthesis process, an automatic process and low costs.
Inventors:
SUN HUNGYU (CN)
QIN NONG (CN)
CHUANG YUNGCHUN (CN)
CHENG YUWEI (CN)
DUAN SHUANGDI (CN)
GAO YATING (CN)
QIN NONG (CN)
CHUANG YUNGCHUN (CN)
CHENG YUWEI (CN)
DUAN SHUANGDI (CN)
GAO YATING (CN)
Application Number:
PCT/CN2022/079288
Publication Date:
September 09, 2022
Filing Date:
March 04, 2022
Export Citation:
Assignee:
UNIV HUNAN (CN)
International Classes:
C07K14/00; A61K38/16; A61P1/16; A61P35/00; C07K1/04; C07K1/06
Domestic Patent References:
| WO2004113501A2 | 2004-12-29 |
Foreign References:
| CN113121650A | 2021-07-16 | |||
| KR20150117185A | 2015-10-19 | |||
| CN110520143A | 2019-11-29 |
Other References:
MENGSHI PAN, HUO YANJIAO, WANG CHENGTAO, ZHANG YANCHUN, DAI ZHIYONG, LI BO: "Positively charged peptides from casein hydrolysate show strong inhibitory effects on LDL oxidation and cellular lipid accumulation in Raw264.7 cells", INTERNATIONAL DAIRY JOURNAL, ELSEVIER APPLIED SCIENCE, BARKING,, GB, vol. 91, 1 April 2019 (2019-04-01), GB , pages 119 - 128, XP055667723, ISSN: 0958-6946, DOI: 10.1016/j.idairyj.2018.09.011
LIU JIAN, WU MING-HAO, XIU SHAN: "EFFECTS OF LIRAGLUTIDE ON RENAL LIPID DEPOSITION OF OBESE RATS", CHENGDE YIXUEYUAN XUEBAO, CHENGDE YIXUEYUAN, JP, vol. 33, no. 1, 15 February 2016 (2016-02-15), JP , pages 1 - 3, XP055965506, ISSN: 1004-6879, DOI: 10.15921/j.cnki.cyxb.2016.01.001
LIU JIAN, WU MING-HAO, XIU SHAN: "EFFECTS OF LIRAGLUTIDE ON RENAL LIPID DEPOSITION OF OBESE RATS", CHENGDE YIXUEYUAN XUEBAO, CHENGDE YIXUEYUAN, JP, vol. 33, no. 1, 15 February 2016 (2016-02-15), JP , pages 1 - 3, XP055965506, ISSN: 1004-6879, DOI: 10.15921/j.cnki.cyxb.2016.01.001
Attorney, Agent or Firm:
ZHUANLI IP LAW FIRM (CN)
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