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Patent Searching and Data


Title:
POLYPEPTIDE MIMICKING DENATURED ANTIBODY
Document Type and Number:
WIPO Patent Application WO/2019/172401
Kind Code:
A1
Abstract:
The present invention provides a molecule that mimics the non-naturally-occurring three-dimensional structure of a denatured antibody, it being possible to use the molecule in quantitative evaluation of the denatured antibody. Specifically, the present invention provides a C-terminal deleted CH3 domain set forth in (i) or (ii): (i) a C-terminal deleted CH3 domain consisting of an amino acid sequence in which an amino acid is deleted within a range of 5-20 residues from the C-terminal side in an amino acid sequence represented by any of SEQ ID NOS: 1-7; or (ii) a C-terminal deleted CH3 domain consisting of an amino acid sequence in which an amino acid is deleted within a range of 5-20 residues from the C-terminal side in an amino acid sequence in which one or several amino acids in an amino acid sequence represented by any of SEQ ID NOS: 1-7 have been substituted, deleted, inserted, and/or added, an AF.2A1 polypeptide specifically binding to said C-terminal deleted CH3 domain.

Inventors:
MIYAFUSA Takamitsu (1-1 Higashi 1-chome, Tsukuba-sh, Ibaraki 66, 〒3058566, JP)
HONDA Shinya (1-1 Higashi 1-chome, Tsukuba-sh, Ibaraki 66, 〒3058566, JP)
Application Number:
JP2019/009244
Publication Date:
September 12, 2019
Filing Date:
March 08, 2019
Export Citation:
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Assignee:
NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY (3-1 Kasumigaseki 1-chome, Chiyoda-ku Tokyo, 21, 〒1008921, JP)
International Classes:
C07K16/18; C12Q1/00; G01N33/15; G01N33/50; G01N33/53; C12N15/13
Attorney, Agent or Firm:
OHNO Seiji et al. (OHNO & PARTNERS, Marunouchi Kitaguchi Building 21F 6-5, Marunouchi 1-chome, Chiyoda-k, Tokyo 05, 〒1000005, JP)
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