POLYPEPTIDE AND PREPARATION METHOD THEREFOR AND USE THEREOF

WIPO Patent Application WO/2024/051616

A1

Provided is a polypeptide, which has: (I) an amino acid sequence set forth in any one of SEQ ID No. 1, SEQ ID No. 4, and SEQ ID No. 5; or (II), an amino acid sequence obtained by substitution, deletion, or addition of one or more amino acids based on the amino acid sequence described in (I) and having the same function as the amino acid sequence described in (I); or (III) an amino acid sequence having a similarity of 80% or more to the amino acid sequence described in (I) or (II); or (IV), a cell-penetrating polypeptide obtained by combining the polypeptide set forth in (I), (II), or (III) with a cell-penetrating peptide; or (V), a stapled peptide obtained by stapling the polypeptide set forth in (I), (II), or (IV). The polypeptide has significant inhibition effect on methylation and METTL3 expression. Further provided are a preparation method for the polypeptide and use of the polypeptide.

SHI JUNFENG (CN)
ZHANG DINGXIAO (CN)
LI ZENGHUI (CN)
FENG YUQING (CN)
WANG MINGSHUI (CN)
HAN HONG (CN)

PCT/CN2023/116629

March 14, 2024

September 01, 2023

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UNIV HUNAN (CN)
GREATER BAY AREA INSTITUTE FOR INNOVATION HUNAN UNIV (CN)

C07K7/06; A61K38/00; A61P31/04; C07K1/04; C07K7/08; C12N15/63

WO2018108185A1	2018-06-21
WO2011008260A2	2011-01-20
WO2016130092A1	2016-08-18

CN113307849A	2021-08-27
CN113336840A	2021-09-03
CN112386678A	2021-02-23
CN112500457A	2021-03-16
CN107056923A	2017-08-18
CN116082447A	2023-05-09

GUANGZHOU KEFENG INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP) (CN)

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