Title:
POLYPEPTIDE TO REDUCE THE QUANTITY OF TARGET PROTEIN, ISOLATED NUCLEIC ACID, RECOMBINANT VECTOR, AND TRANSFORMANT
Document Type and Number:
WIPO Patent Application WO/2015/133611
Kind Code:
A1
Abstract:
To provide a technique of specifically reducing the quantity of target protein. Provided is a polypeptide comprising an amino acid sequence, having at least a protein region containing an amino acid sequence that specifically binds to a target protein, and an amino acid sequence that binds to Hsc70. The protein region may be a Tpp1 region. A linker sequence and/or a spacer sequence may be interposed between the protein region and the amino acid sequence that binds to Hsc70.
Inventors:
TORIGOE HIDETAKA (JP)
TATSUZAWA SAKURAKO (JP)
MORI MASATADA (JP)
KOBAYASHI YURIKA (JP)
TATSUZAWA SAKURAKO (JP)
MORI MASATADA (JP)
KOBAYASHI YURIKA (JP)
Application Number:
PCT/JP2015/056670
Publication Date:
September 11, 2015
Filing Date:
March 06, 2015
Export Citation:
Assignee:
UNIV TOKYO SCIENCE FOUNDATION (JP)
International Classes:
C12N15/09; A01K67/027; C07K14/47; C07K14/705; C07K16/00; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10
Domestic Patent References:
| WO2005097189A1 | 2005-10-20 |
Other References:
BAUER PO ET AL.: "Harnessing chaperone-mediated autophagy for the selective degradation of mutant huntingtin protein", NAT. BIOTECHNOL., vol. 28, no. 3, 2010, pages 256 - 263
YOSHITAKA NAGAI ET AL.: "Selective degradation of expanded polyglutamine proteins by their specific recognition with QBP1", CLINICAL NEUROLOGY, vol. 51, no. 11, 2011, pages 1108 - 1110
SAKURAKO TATSUZAWA ET AL.: "Development of a novel method to artificially degrade target proteins using chaperone-mediated autophagy mechanism", PROTEIN SCIENCE SOCIETY OF JAPAN NENKAI PROGRAM YOSHISHU, vol. 14, 26 May 2014 (2014-05-26), pages 102
CHEN LY ET AL.: "Mitochondrial localization of telomeric protein TIN2 links telomere regulation to metabolic control", MOL. CELL, vol. 47, no. 6, 2012, pages 839 - 850
YAMADA K ET AL.: "Decreased gene expression for telomeric-repeat binding factors and TIN2 in malignant hematopoietic cells", ANTICANCER RES., vol. 22, no. 2B, 2002, pages 1315 - 1320
ABREU EL ET AL.: "TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo", MOL. CELL . BIOL., vol. 30, no. 12, 2010, pages 2971 - 2982
O'CONNOR MS ET AL.: "A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly", PROC. NATL. ACAD. SCI. USA, vol. 103, no. 32, 2006, pages 11874 - 11879
MARTINEZ P ET AL.: "Telomeric and extra- telomeric roles for telomerase and the telomere-binding proteins", NAT. REV. CANCER, vol. 11, no. 3, 2011, pages 161 - 176
ELOY B ET AL.: "Chaperone-mediated autophagy", PROC. AM. THORAC. SOC., vol. 7, no. 1, 2010, pages 29 - 39
DICE JF: "Chaperone-mediated autophagy", AUTOPHAGY, vol. 3, no. 4, 2007, pages 295 - 299
YOSHITAKA NAGAI ET AL.: "Selective degradation of expanded polyglutamine proteins by their specific recognition with QBP1", CLINICAL NEUROLOGY, vol. 51, no. 11, 2011, pages 1108 - 1110
SAKURAKO TATSUZAWA ET AL.: "Development of a novel method to artificially degrade target proteins using chaperone-mediated autophagy mechanism", PROTEIN SCIENCE SOCIETY OF JAPAN NENKAI PROGRAM YOSHISHU, vol. 14, 26 May 2014 (2014-05-26), pages 102
CHEN LY ET AL.: "Mitochondrial localization of telomeric protein TIN2 links telomere regulation to metabolic control", MOL. CELL, vol. 47, no. 6, 2012, pages 839 - 850
YAMADA K ET AL.: "Decreased gene expression for telomeric-repeat binding factors and TIN2 in malignant hematopoietic cells", ANTICANCER RES., vol. 22, no. 2B, 2002, pages 1315 - 1320
ABREU EL ET AL.: "TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo", MOL. CELL . BIOL., vol. 30, no. 12, 2010, pages 2971 - 2982
O'CONNOR MS ET AL.: "A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly", PROC. NATL. ACAD. SCI. USA, vol. 103, no. 32, 2006, pages 11874 - 11879
MARTINEZ P ET AL.: "Telomeric and extra- telomeric roles for telomerase and the telomere-binding proteins", NAT. REV. CANCER, vol. 11, no. 3, 2011, pages 161 - 176
ELOY B ET AL.: "Chaperone-mediated autophagy", PROC. AM. THORAC. SOC., vol. 7, no. 1, 2010, pages 29 - 39
DICE JF: "Chaperone-mediated autophagy", AUTOPHAGY, vol. 3, no. 4, 2007, pages 295 - 299
Attorney, Agent or Firm:
SHOBAYASHI, Masayuki (JP)
Right wood Masayuki (JP)
Right wood Masayuki (JP)
Download PDF:
Previous Patent: METHOD FOR PRODUCING RUBBER COMPOSITION
Next Patent: TRANSPARENT FLUORESCENT SIALON CERAMIC AND METHOD FOR PRODUCING SAME
Next Patent: TRANSPARENT FLUORESCENT SIALON CERAMIC AND METHOD FOR PRODUCING SAME