Title:
POLYPEPTIDE VARIANTS WITH ALTERED EFFECTOR FUNCTION
Document Type and Number:
WIPO Patent Application WO2000042072
Kind Code:
A3
Abstract:
The present invention concerns polypeptides comprising a variant Fc region. More particularly, the present invention concerns Fc region-containing polypeptides that have altered effector function as a consequence of one or more amino acid modifications in the Fc region thereof.
Inventors:
PRESTA LEONARD G
Application Number:
PCT/US2000/000973
Publication Date:
November 30, 2000
Filing Date:
January 14, 2000
Export Citation:
Assignee:
GENENTECH INC (US)
International Classes:
A61K38/00; A61P11/06; A61P35/00; A61P37/08; A61P43/00; C07K16/00; C07K16/18; C07K16/22; C07K16/28; G01N33/53; C07K16/42; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12N15/13; C12P21/02; G01N33/566; (IPC1-7): C07K16/00; A61K39/395; C12N15/13; C12N15/85; C12N5/10; G01N33/68; G01N33/577; C07K16/22
Domestic Patent References:
| WO1998023289A1 | 1998-06-04 | |||
| WO1999051642A1 | 1999-10-14 |
Foreign References:
| US5624821A | 1997-04-29 |
Other References:
SARMAY G ET AL: "MAPPING AND COMPARISON OF THE INTERACTION SITES ON THE FC REGION OF IGG RESPONSIBLE FOR TRIGGERING ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY ADCC THROUGH DIFFERENT TYPES OF HUMAN FC-GAMMA RECEPTOR", MOLECULAR IMMUNOLOGY, vol. 29, no. 5, 1992, pages 633 - 639, XP000915240, ISSN: 0161-5890
GHETIE VICTOR ET AL: "Increasing the serum persistence of an IgG fragment by random mutagenesis.", NATURE BIOTECHNOLOGY, vol. 15, no. 7, 1997, pages 637 - 640, XP000876642, ISSN: 1087-0156
MEDESAN CORNELIU ET AL: "Comparative studies of rat IgG to further delineate the Fc:FcRn interaction site.", EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 28, no. 7, July 1998 (1998-07-01), pages 2092 - 2100, XP000915239, ISSN: 0014-2980
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 16 December 1997 (1997-12-16), HENRY ALISTAIR J ET AL: "Participation of the N-terminal region of Cepsilon3 in the binding of human IgE to its high-affinity receptor FcepsilonRI.", XP002142066, Database accession no. PREV199800070240
GHETIE VICTOR ET AL: "Increasing the serum persistence of an IgG fragment by random mutagenesis.", NATURE BIOTECHNOLOGY, vol. 15, no. 7, 1997, pages 637 - 640, XP000876642, ISSN: 1087-0156
MEDESAN CORNELIU ET AL: "Comparative studies of rat IgG to further delineate the Fc:FcRn interaction site.", EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 28, no. 7, July 1998 (1998-07-01), pages 2092 - 2100, XP000915239, ISSN: 0014-2980
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 16 December 1997 (1997-12-16), HENRY ALISTAIR J ET AL: "Participation of the N-terminal region of Cepsilon3 in the binding of human IgE to its high-affinity receptor FcepsilonRI.", XP002142066, Database accession no. PREV199800070240
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