Title:
POLYPEPTIDES CLEAVING TELOMERIC REPEATS
Document Type and Number:
WIPO Patent Application WO/2001/088149
Kind Code:
A1
Abstract:
DNAs encoding polypeptides which cleave telomeric repeats are successfully isolated form a retrotransposon-like sequences present in the telomeric repeats of genomic DNA. The polypeptides encoded by the above DNAs show an activity of cleaving telomeric repeats of insects and vertebrates. Thus, polypeptides cleaving telomeric repeats, DNAs encoding these polypeptides and the production and use thereof are provided. These polypeptides are usable in specifically cleaving telomeric repeats. Moreover, these polypeptides are applicable to the control of cell aging and treatment of cancer.
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Inventors:
FUJIWARA HARUHIKO (JP)
Application Number:
PCT/JP2000/008242
Publication Date:
November 22, 2001
Filing Date:
November 22, 2000
Export Citation:
Assignee:
CT FOR ADVANCED SCIENCE & TECH (JP)
FUJIWARA HARUHIKO (JP)
FUJIWARA HARUHIKO (JP)
International Classes:
C12N9/12; C12N15/55; A61K38/00; (IPC1-7): C12N15/55; C07K14/435; C12N5/16; C12P21/02; C12Q1/38
Other References:
Anzai T., Takahashi H., Fujiwara H., "Sequence-Specific Recognition and Cleavage of Telomeric Repeat (TTAGG)(n) by Endonuclease of Non-Long Terminal Repeat Retrotransposon TRAS1", Mol. Cell. Biol. (January 2001), Vol. 21, No. 1, pages 100-108.
Okazaki S., et al., "Structural analysis of TRAS1, a novel family of telomeric repeat-associated retrotransposons in the silkwork, Bombyx mori", Mol. Cell. Biol. (1995), Vol. 15, No. 8, pages 4545-4552.
Takahashi H., Okazaki S., Fujiwara H., "A new family of site-specific retrotransposons, SART1, is inserted into telomeric repeats of the silkworm, Bombyx mori", Nucleic Acids Res. (1997), Vol. 25, No. 8, pages 1578-1584.
Haruhiko FUJIWARA et al., "Senshokutai no Mattan = Telomere no Keisei ni kakawaru RNA", Iden (July 1994), Vol. 48, No. 7, pages 57-61.
Okazaki S., et al., "Structural analysis of TRAS1, a novel family of telomeric repeat-associated retrotransposons in the silkwork, Bombyx mori", Mol. Cell. Biol. (1995), Vol. 15, No. 8, pages 4545-4552.
Takahashi H., Okazaki S., Fujiwara H., "A new family of site-specific retrotransposons, SART1, is inserted into telomeric repeats of the silkworm, Bombyx mori", Nucleic Acids Res. (1997), Vol. 25, No. 8, pages 1578-1584.
Haruhiko FUJIWARA et al., "Senshokutai no Mattan = Telomere no Keisei ni kakawaru RNA", Iden (July 1994), Vol. 48, No. 7, pages 57-61.
Attorney, Agent or Firm:
Shimizu, Hatsushi (Oroshi-machi Tsuchiura-shi, Ibaraki, JP)
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