Title:
POLYPEPTIDES DERIVED FROM ENTEROCOCCUS AND THEIR USE FOR VACCINATION AND THE GENERATION OF THERAPEUTIC ANTIBODIES
Document Type and Number:
WIPO Patent Application WO/2015/132103
Kind Code:
A3
Abstract:
Medicament for the treatment or the prevention of a bacterial infection, characterized in that it contains at least one polypeptide selected from the group of SEQ ID NO: 1 to SEQ ID NO: 9, and contiguous fragments thereof, wherein said at least one polypeptide or contiguous fragment thereof induces opsonic antibodies in a patient in need thereof. The polypeptides or the contiguous fragments thereof according to the present invention can be used for the preparation of a vaccine against an infection against Enterococcus.
Inventors:
HÜBNER JOHANNES (DE)
HARTKE AXEL (FR)
ROMERO FELIPE (DE)
HARTKE AXEL (FR)
ROMERO FELIPE (DE)
Application Number:
PCT/EP2015/053948
Publication Date:
November 26, 2015
Filing Date:
February 25, 2015
Export Citation:
Assignee:
ALBERT LUDWIGS UNIVERSITÄT FREIBURG (DE)
UNIV CAEN BASSE NORMANDIE (FR)
UNIV CAEN BASSE NORMANDIE (FR)
International Classes:
A61P31/04; A61K39/02; C07K14/24; C07K16/12
Foreign References:
| EP2248533A1 | 2010-11-10 |
Other References:
DATABASE UniProt [online] 26 June 2013 (2013-06-26), "SubName: Full=Penicillin-binding protein transpeptidase;", XP002726914, retrieved from EBI accession no. UNIPROT:R3ZLV9 Database accession no. R3ZLV9
A. KROPEC ET AL: "Identification of SagA as a novel vaccine target for the prevention of Enterococcus faecium infections", MICROBIOLOGY, vol. 157, no. 12, 8 September 2011 (2011-09-08), pages 3429 - 3434, XP055097028, ISSN: 1350-0872, DOI: 10.1099/mic.0.053207-0
SAVA I G ET AL: "Enterococcal surface protein contributes to persistence in the host but is not a target of opsonic and protective antibodies in Enterococcus faecium infection", JOURNAL OF MEDICAL MICROBIOLOGY, vol. 59, no. 9, September 2010 (2010-09-01), pages 1001 - 1004, XP002726915, ISSN: 0022-2615
SADOWY E ET AL: "High abundance and diversity of antimicrobial resistance determinants among early vancomycin-resistant Enterococcus faecium in Poland.", EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES : OFFICIAL PUBLICATION OF THE EUROPEAN SOCIETY OF CLINICAL MICROBIOLOGY SEP 2013, vol. 32, no. 9, September 2013 (2013-09-01), pages 1193 - 1203, XP002726916, ISSN: 1435-4373
A. KROPEC ET AL: "Identification of SagA as a novel vaccine target for the prevention of Enterococcus faecium infections", MICROBIOLOGY, vol. 157, no. 12, 8 September 2011 (2011-09-08), pages 3429 - 3434, XP055097028, ISSN: 1350-0872, DOI: 10.1099/mic.0.053207-0
SAVA I G ET AL: "Enterococcal surface protein contributes to persistence in the host but is not a target of opsonic and protective antibodies in Enterococcus faecium infection", JOURNAL OF MEDICAL MICROBIOLOGY, vol. 59, no. 9, September 2010 (2010-09-01), pages 1001 - 1004, XP002726915, ISSN: 0022-2615
SADOWY E ET AL: "High abundance and diversity of antimicrobial resistance determinants among early vancomycin-resistant Enterococcus faecium in Poland.", EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES : OFFICIAL PUBLICATION OF THE EUROPEAN SOCIETY OF CLINICAL MICROBIOLOGY SEP 2013, vol. 32, no. 9, September 2013 (2013-09-01), pages 1193 - 1203, XP002726916, ISSN: 1435-4373
Attorney, Agent or Firm:
KRAUSS, Jan, B. (Pettenkoferstraße 20-22, München, DE)
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