POLYPEPTIDES HAVING ACTIVITY OF STIMULATING NEUTROPHILS

Title:

POLYPEPTIDES HAVING ACTIVITY OF STIMULATING NEUTROPHILS

Document Type and Number:

WIPO Patent Application WO/2001/066734

Kind Code:

A1

Abstract:

A factor capable of attracting and activating neutrophils which might be prepared by normal cells. A polypeptide having an activity of stimulating neutrophils is isolated from an extract obtained from healthy swine heart. Namely, provision is made of: (a) a polypeptide comprising the amino acid sequence represented by SEQ ID NO:1; (b) a polypeptide comprising an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO:1 by deletion, substitution or insertion of one to several amino acids and having the activity of stimulating neutrophils; and (c) a polypeptide comprising an amino acid sequence which is biologically equivalent to the amino acid sequence of the polypeptide (a) or (b) as described above.

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Inventors:

MUKAI HIDEHITO (JP)
NISHI YOSHISUKE (JP)
MUNEKATA EISUKE (JP)

Application Number:

PCT/JP2001/001729

Publication Date:

September 13, 2001

Filing Date:

March 06, 2001

Export Citation:

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Assignee:

JAPAN TOBACCO INC (JP)
MUKAI HIDEHITO (JP)
NISHI YOSHISUKE (JP)
MUNEKATA EISUKE (JP)

International Classes:

C07K14/47; C07K14/80; C12N15/12; A61K38/00; (IPC1-7): C12N15/12; C07K14/47; C07K16/18; G01N33/68

Domestic Patent References:

WO1990006321A1

1990-06-14

Foreign References:

JPH0820600A	1996-01-23
EP0538030A2	1993-04-21

Other References:

KOWNATZKI E. ET AL.: "Production of superoxide anion and hydrogen peroxide by human neutrophilic granulocytes...", INT. ARCH. ALLERGY APPL. IMMUNOL., vol. 93, no. 4, 1990, pages 344 - 349, XP002941488
TAKENOUCHI T. ET AL.: "Beta-amyloid peptide, substance P and SEC receptor ligand activate cytoplasmic Ca2+...", PEPTIDES, vol. 16, no. 6, 1995, pages 1019 - 1024, XP002941489

Attorney, Agent or Firm:

Shamoto, Ichio (New Ohtemachi Bldg. 2-1 Ohtemachi 2-chome Chiyoda-ku, Tokyo, JP)

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