Title:
POLYPEPTIDES AND METHOD OF TREATMENT
Document Type and Number:
WIPO Patent Application WO/2011/002968
Kind Code:
A3
Abstract:
Provided herein are isolated antigen binding protein comprising at least one first immunoglobulin variable domain capable of binding to human ADAMTS5. Also provided are antigen binding proteins of the present invention that are monoclonal antibodies, pharmaceutical compositions comprising said antigen binding proteins and methods of treatment.
Inventors:
BURDEN MICHAEL NEIL (GB)
HAMBLIN PAUL ANDREW (GB)
LARKIN JONATHAN DAVID (US)
WHITE JOHN RICHARD (US)
HAMBLIN PAUL ANDREW (GB)
LARKIN JONATHAN DAVID (US)
WHITE JOHN RICHARD (US)
Application Number:
PCT/US2010/040724
Publication Date:
April 07, 2011
Filing Date:
July 01, 2010
Export Citation:
Assignee:
GLAXO GROUP LTD (US)
BURDEN MICHAEL NEIL (GB)
HAMBLIN PAUL ANDREW (GB)
LARKIN JONATHAN DAVID (US)
WHITE JOHN RICHARD (US)
BURDEN MICHAEL NEIL (GB)
HAMBLIN PAUL ANDREW (GB)
LARKIN JONATHAN DAVID (US)
WHITE JOHN RICHARD (US)
International Classes:
C12P21/08
Foreign References:
| US20080311113A1 | 2008-12-18 |
Other References:
STEIDL ET AL.: "In vitro affinity maturation of human GM-CSF antibodies by targeted CDR- diversification.", MOL IMMUNOL., vol. 46, no. 1, 2008, pages 135 - 44, XP025472134
TABRIZI ET AL.: "Elimination mechanisms of therapeutic monoclonal antibodies.", DRUG DISCOVERY TODAY, vol. 11, no. 1-2, 2006, pages 81 - 88, XP025027052
MATSUMOTO ET AL.: "Expression of ADAMTS-5 in deformed human temporomandibular joint discs.", HISTOL HISTOPATHOL., vol. 23, no. 12, 2008, pages 1485 - 93, XP008150105
SIEUWERTS ET AL.: "Study Patients with Recurrent Breast Cancer: a Retrospective Receptor Predict Response to Tamoxifen Treatment in How ADAM-9 and ADAM-11 Differentially From Estrogen.", CLIN CANCER RES, vol. 11, no. 20, 2005, pages 7311 - 7321, XP008150111
TAKAHASHI ET AL.: "Deficits in spatial learning and motor coordination in ADAM11-deficient mice BMC Neuroscience", vol. 7, 2006, pages 19, XP008150112, Retrieved from the Internet [retrieved on 20110112]
TABRIZI ET AL.: "Elimination mechanisms of therapeutic monoclonal antibodies.", DRUG DISCOVERY TODAY, vol. 11, no. 1-2, 2006, pages 81 - 88, XP025027052
MATSUMOTO ET AL.: "Expression of ADAMTS-5 in deformed human temporomandibular joint discs.", HISTOL HISTOPATHOL., vol. 23, no. 12, 2008, pages 1485 - 93, XP008150105
SIEUWERTS ET AL.: "Study Patients with Recurrent Breast Cancer: a Retrospective Receptor Predict Response to Tamoxifen Treatment in How ADAM-9 and ADAM-11 Differentially From Estrogen.", CLIN CANCER RES, vol. 11, no. 20, 2005, pages 7311 - 7321, XP008150111
TAKAHASHI ET AL.: "Deficits in spatial learning and motor coordination in ADAM11-deficient mice BMC Neuroscience", vol. 7, 2006, pages 19, XP008150112, Retrieved from the Internet
Attorney, Agent or Firm:
DERMOTT, Jonathan, M. et al. (Corporate Intellectual Property UW2220,709 Swedeland Road, P.O. Box 153, King Of Prussia PA, US)
Download PDF:
Previous Patent: METHOD FOR PRINTING A MATERIAL ONTO A SUBSTRATE
Next Patent: APPARATUS AND METHODS FOR PRODUCING CHARGED FLUID DROPLETS
Next Patent: APPARATUS AND METHODS FOR PRODUCING CHARGED FLUID DROPLETS