Title:
POLYPEPTIDES WITH TRANSPOSITIONAL ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2023/036877
Kind Code:
A3
Abstract:
The present invention relates to polypeptides with transpositional activity, particularly engineered polypeptides with transpositional activity, nucleic acids encoding such polypeptides, vectors compris- ing said nucleic acids, a cell comprising said nucleic acid, methods of integrating an exogenous nucle- ic acid into the genome using said polypeptides, said polypeptides for use in medicine and/or several gene therapies; and a pharmaceutical composition comprising said polypeptides, nucleic acids, vectors or cells. Particularly, the present invention relates to said polypeptide, which is engineered to have a gain of specificity of integration into the genome.
Inventors:
IVICS ZOLTAN (DE)
KESSELRING LISA (DE)
MISKEY CSABA (DE)
KESSELRING LISA (DE)
MISKEY CSABA (DE)
Application Number:
PCT/EP2022/075007
Publication Date:
July 20, 2023
Filing Date:
September 08, 2022
Export Citation:
Assignee:
MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN HELMHOLTZ GEMEINSCHAFT (DE)
International Classes:
C12N9/22; A61K38/00; A61K38/45; A61K48/00; C07K14/00; C12N15/90
Foreign References:
| US20050003542A1 | 2005-01-06 | |||
| US20110117072A1 | 2011-05-19 |
Other References:
FRANKA VOIGT ET AL: "Sleeping Beauty transposase structure allows rational design of hyperactive variants for genetic engineering", NATURE COMMUNICATIONS, vol. 7, no. 1, 30 March 2016 (2016-03-30), XP055697414, DOI: 10.1038/ncomms11126
DATABASE Geneseq [online] 19 June 2014 (2014-06-19), "Hypophthalmichthys molitrix Thm3 transposase, SEQ ID 24.", XP002805826, retrieved from EBI accession no. GSP:BBF14943 Database accession no. BBF14943
DATABASE Geneseq [online] 19 June 2014 (2014-06-19), "Hypophthalmichthys molitrix Thm3 transposase, SEQ ID 24.", XP002805826, retrieved from EBI accession no. GSP:BBF14943 Database accession no. BBF14943
Attorney, Agent or Firm:
MORÉ, Solveig (DE)
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