Title:
POLYPLEXES
Document Type and Number:
WIPO Patent Application WO/2014/169256
Kind Code:
A3
Abstract:
The present disclosure relates to compounds comprising (i) an active agent, wherein the active agent includes a charge at a predetermined pH, (ii) a polymer, wherein the polymer includes an opposite charge than the active agent at the predetermined pH; and (iii) a polyplex comprising the peptide and the polymer electrostatically bond together at the predetermined pH. In some embodiments, the active agent is a peptide, such as a peptide comprising MAPKAP kinase II inhibitory peptide, and in some embodiments the peptide includes a cell-penetrating peptide. In further embodiments, the disclosure provides methods for treating a disease or condition by administering a composition according to the present disclosure to a subject in need thereof.
Inventors:
DUVALL CRAIG (US)
EVANS BRIAN CONNOR (US)
BROPHY COLLEEN (US)
HOCKING KYLE (US)
EVANS BRIAN CONNOR (US)
BROPHY COLLEEN (US)
HOCKING KYLE (US)
Application Number:
PCT/US2014/033873
Publication Date:
December 11, 2014
Filing Date:
April 11, 2014
Export Citation:
Assignee:
UNIV VANDERBILT (US)
International Classes:
A61K8/91
Domestic Patent References:
| WO2009021137A2 | 2009-02-12 | |||
| WO2007001448A2 | 2007-01-04 |
Foreign References:
| EP2284210A1 | 2011-02-16 | |||
| EP2138575B1 | 2013-06-19 |
Other References:
MUTO ET AL.: "Inhibition of Mitogen Activated Protein Kinase Activated Protein Kinase II with MMI-0100 reduces intimal hyperplasia ex vivo and in vivo", VASCULAR PHARMACOLOGY, vol. 56, 1 January 2012 (2012-01-01), pages 47 - 55, XP055254632, DOI: doi:10.1016/j.vph.2011.07.008
See also references of EP 2991616A4
See also references of EP 2991616A4
Attorney, Agent or Firm:
DAVIDSON, Nicolo B. et al. (401 Commerce StreetNashville, Tennessee, US)
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