Title:
POLYROTAXANE COMPRISING CYCLIC MOLECULE WITH ALDEHYDE GROUP ADDUCT, METHOD FOR PRODUCING SAID POLYROTAXANE, STRETCHABLE BIOMATERIAL, AND METHOD FOR PRODUCING SAID BIOMATERIAL
Document Type and Number:
WIPO Patent Application WO/2024/038783
Kind Code:
A1
Abstract:
[Problem] The present invention addresses the problem of developing a stretchable biomaterial (in particular, a stretchable collagen). [Solution] The present inventors: found a method for producing a polyrotaxane comprising a cyclic molecule with an aldehyde group adduct, by which it is possible to specifically add an aldehyde group to a cyclic molecule of the polyrotaxane; found a method for producing a stretchable biomaterial, the method including a crosslinking method which can suppress reductive amination and the generation of free aldehydes; and further, confirmed that a filamentous collagen is stretchable, leading to the completion of the present disclosure.
Inventors:
KUBOTA RIKU (JP)
FUJIMOTO ICHIRO (JP)
FUJIMOTO ICHIRO (JP)
Application Number:
PCT/JP2023/028657
Publication Date:
February 22, 2024
Filing Date:
August 04, 2023
Export Citation:
Assignee:
KOKEN KK (JP)
International Classes:
A61L27/26; A61L17/10; A61L31/04; C08B37/16; C08G65/331
Foreign References:
| JP2020180228A | 2020-11-05 | |||
| JP2020537581A | 2020-12-24 | |||
| JP2016537685A | 2016-12-01 | |||
| JP2016506422A | 2016-03-03 | |||
| JP2000516828A | 2000-12-19 | |||
| JP2005320392A | 2005-11-17 |
Other References:
LEI XIAOYUE, JIA YONG-GUANG, SONG WENJING, QI DAWEI, JIN JIAHONG, LIU JIA, REN LI: "Mechanical and Optical Properties of Reinforced Collagen Membranes for Corneal Regeneration through Polyrotaxane Cross-Linking", ACS APPLIED BIO MATERIALS, AMERICAN CHEMICAL SOCIETY, US, vol. 2, no. 9, 16 September 2019 (2019-09-16), US , pages 3861 - 3869, XP093140275, ISSN: 2576-6422, DOI: 10.1021/acsabm.9b00464
ZHAO XUAN, SONG WENJING, LI WEICHANG, LIU SA, WANG LIN, REN LI: "Collagen membranes crosslinked by β-cyclodextrin polyrotaxane monoaldehyde with good biocompatibilities and repair capabilities for cornea repair", RSC ADVANCES, ROYAL SOCIETY OF CHEMISTRY, GB, vol. 7, no. 46, 1 January 2017 (2017-01-01), GB , pages 28865 - 28875, XP093140280, ISSN: 2046-2069, DOI: 10.1039/C7RA03994H
ZHAO XUAN, SONG WENJING, LI WEICHANG, LIU SA, WANG LIN, REN LI: "Collagen membranes crosslinked by β-cyclodextrin polyrotaxane monoaldehyde with good biocompatibilities and repair capabilities for cornea repair", RSC ADVANCES, ROYAL SOCIETY OF CHEMISTRY, GB, vol. 7, no. 46, 1 January 2017 (2017-01-01), GB , pages 28865 - 28875, XP093140280, ISSN: 2046-2069, DOI: 10.1039/C7RA03994H
Attorney, Agent or Firm:
SHOJI Takashi et al. (JP)
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