Title:
POLYSACCHARIDE - STAPHYLOCOCCAL SURFACE ADHESIN CARRIER PROTEIN CONJUGATES FOR IMMUNIZATION AGAINST NOSOCOMIAL INFECTIONS
Document Type and Number:
WIPO Patent Application WO2004080490
Kind Code:
A3
Abstract:
Immunogenic polysaccharide-protein conjugates having a polysaccharide antigen (or its oligosaccharide fragment representing one or more antigenic epitopes) derived from a nosocomial pathogen conjugated to a staphylococcal surface adhesin carrier protein are used in immunogenic compositions to elicit antibody responses to both the polysaccharide antigen and the staphylococcal surface adhesion carrier protein. Such immunogenic compositions are used to immunize against diseases caused by Staphylococcal aureus, Staphylococcal epidermidis or other nosocomial pathogens.
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Inventors:
PAVLIAK VILIAM (US)
BAKER STEVEN MORRIS (US)
PILLAI SUBRAMONIA PADMANABA (US)
BAKER STEVEN MORRIS (US)
PILLAI SUBRAMONIA PADMANABA (US)
Application Number:
PCT/US2004/006661
Publication Date:
October 28, 2004
Filing Date:
March 04, 2004
Export Citation:
Assignee:
WYETH CORP (US)
PAVLIAK VILIAM (US)
BAKER STEVEN MORRIS (US)
PILLAI SUBRAMONIA PADMANABA (US)
PAVLIAK VILIAM (US)
BAKER STEVEN MORRIS (US)
PILLAI SUBRAMONIA PADMANABA (US)
International Classes:
A61K39/085; A61K47/48; (IPC1-7): A61K47/48; C07K16/12; A61K39/385
Domestic Patent References:
| WO2001072337A1 | 2001-10-04 | |||
| WO2001070685A2 | 2001-09-27 | |||
| WO1995008348A1 | 1995-03-30 | |||
| WO2000056359A2 | 2000-09-28 | |||
| WO1999003871A1 | 1999-01-28 | |||
| WO1994010317A2 | 1994-05-11 | |||
| WO2000012131A1 | 2000-03-09 | |||
| WO2000071585A1 | 2000-11-30 | |||
| WO1986006635A1 | 1986-11-20 | |||
| WO2003076470A1 | 2003-09-18 | |||
| WO2003061558A2 | 2003-07-31 |
Foreign References:
| EP1034792A1 | 2000-09-13 | |||
| CA2351018A1 | 2003-01-09 | |||
| US20030068336A1 | 2003-04-10 |
Other References:
FATTOM A ET AL: "Laboratory and clinical evaluation of conjugate vaccines composed of Staphylococcus aureus type 5 and type 8 capsular polysaccharides bound to Pseudomonas aeruginosa recombinant exoprotein A", INFECTION AND IMMUNITY, AMERICAN SOCIETY FOR MICROBIOLOGY. WASHINGTON, US, vol. 61, no. 3, March 1993 (1993-03-01), pages 1023 - 1032, XP001109265, ISSN: 0019-9567
FATTOM A I ET AL: "A Staphylococcus aureus capsular polysaccharide (CP) vaccine and CP- specific antibodies protect mice against bacterial challenge", INFECTION AND IMMUNITY 1996 UNITED STATES, vol. 64, no. 5, 1996, pages 1659 - 1665, XP002293940, ISSN: 0019-9567
SCHNEERSON R ET AL: "Evaluation of monophosphoryl lipid A (MPL) as an adjuvant: Enhancement of the serum antibody response in mice to polysaccharide-protein conjugates by concurrent injection with MPL", JOURNAL OF IMMUNOLOGY, THE WILLIAMS AND WILKINS CO. BALTIMORE, US, vol. 147, no. 7, 1991, pages 2136 - 2140, XP002149961, ISSN: 0022-1767
SHINEFIELD H ET AL: "Use of a Staphylococcus aureus conjugate vaccine in patients receiving hemodialysis", NEW ENGLAND JOURNAL OF MEDICINE 14 FEB 2002 UNITED STATES, vol. 346, no. 7, 14 February 2002 (2002-02-14), pages 491 - 496, XP002967410, ISSN: 0028-4793
WELCH P G ET AL: "Safety and immunogenicity of staphylococcus aureus type 5 capsular polysaccharide-pseudomonas aeruginosa recombinant exoprotein A conjugate vaccine in patients on hemodialysis", JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, WILLIAMS AND WILKINS, BALTIMORE, MD, US, vol. 7, 1996, pages 247 - 253, XP002967409, ISSN: 1046-6673
KONADU E ET AL: "Preparation, characterization, and immunological properties in mice of Escherichia coli O157 O-specific polysaccharide-protein conjugate vaccines", INFECTION AND IMMUNITY, AMERICAN SOCIETY FOR MICROBIOLOGY. WASHINGTON, US, vol. 62, no. 11, November 1994 (1994-11-01), pages 5048 - 5054, XP002912809, ISSN: 0019-9567
DEVI S J N ET AL: "Antibodies to poly[(2->8)-[alpha]-N-acetylneuraminic acid] and poly[(2->9)-[alpha]-N-acetylneuraminic acid] are elicited by immunization of mice with Escherichia coli K92 conjugates: Potential vaccines for groups B and C meningococci and E. coli K1", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 88, no. 16, 15 August 1991 (1991-08-15), pages 7175 - 7179, XP002044636, ISSN: 0027-8424
JOSEFSSON E ET AL: "PROTECTION AGAINST STAPHYLOCOCCUS AUREUS ARTHRITIS BY VACCINATION WITH CLUMPING FACTOR A, A NOVEL VIRULENCE DETERMINANT", IMMUNOLOGY LETTERS, AMSTERDAM, NL, vol. 73, no. 2/3, September 2000 (2000-09-01), pages 153 - 154, XP009029019, ISSN: 0165-2478
JOSEFSSON E ET AL: "Protection against experimental Staphylococcus aureus arthritis by vaccination with clumping factor A, a novel virulence determinant", JOURNAL OF INFECTIOUS DISEASES, CHICAGO, IL, US, vol. 184, no. 12, 15 December 2001 (2001-12-15), pages 1572 - 1580, XP009028976, ISSN: 0022-1899
CASOLINI F ET AL: "Antibody response to fibronectin-binding adhesin FnbpA in patients with Staphylococcus aureus infections", INFECTION AND IMMUNITY, AMERICAN SOCIETY FOR MICROBIOLOGY. WASHINGTON, US, vol. 66, no. 11, November 1998 (1998-11-01), pages 5433 - 5442, XP002222372, ISSN: 0019-9567
MAMO W ET AL: "VACCINATION WITH STAPHYLOCOCCUS AUREUS FIBRINOGEN BINDING PROTEINS (FGBPS) REDUCES COLONISATION OF S. AUREUS IN A MOUSE MASTITIS MODEL", FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY, ELSEVIER SCIENCE B.V., AMSTERDAM, NL, vol. 10, no. 1, 1 November 1994 (1994-11-01), pages 47 - 54, XP000619735, ISSN: 0928-8244
FATTOM A ET AL: "Effect of conjugation methodology, carrier protein, and adjuvants on the immune response to Staphylococcus aureus capsular polysaccharides", VACCINE, BUTTERWORTH SCIENTIFIC. GUILDFORD, GB, vol. 13, no. 14, 1 October 1995 (1995-10-01), pages 1288 - 1293, XP004057429, ISSN: 0264-410X
PARK HEE-MYUNG ET AL: "Immunogenicity of alpha-toxin, capsular polysaccharide (CPS) and recombinant fibronectin-binding protein (r-FnBP) of Staphylococcus aureus in rabbit", JOURNAL OF VETERINARY MEDICAL SCIENCE, vol. 61, no. 9, September 1999 (1999-09-01), pages 995 - 1000, XP002293941, ISSN: 0916-7250
HAN HONG RYUL ET AL: "Determination of alpha-toxin antibodies against Staphylococcus aureus and phagocytic ability postimmunization in rabbits", BOVINE PRACTITIONER, no. 32 PART 1, January 1998 (1998-01-01), pages 14 - 17, XP008034262, ISSN: 0524-1685 0524-1685
FATTOM A I ET AL: "A Staphylococcus aureus capsular polysaccharide (CP) vaccine and CP- specific antibodies protect mice against bacterial challenge", INFECTION AND IMMUNITY 1996 UNITED STATES, vol. 64, no. 5, 1996, pages 1659 - 1665, XP002293940, ISSN: 0019-9567
SCHNEERSON R ET AL: "Evaluation of monophosphoryl lipid A (MPL) as an adjuvant: Enhancement of the serum antibody response in mice to polysaccharide-protein conjugates by concurrent injection with MPL", JOURNAL OF IMMUNOLOGY, THE WILLIAMS AND WILKINS CO. BALTIMORE, US, vol. 147, no. 7, 1991, pages 2136 - 2140, XP002149961, ISSN: 0022-1767
SHINEFIELD H ET AL: "Use of a Staphylococcus aureus conjugate vaccine in patients receiving hemodialysis", NEW ENGLAND JOURNAL OF MEDICINE 14 FEB 2002 UNITED STATES, vol. 346, no. 7, 14 February 2002 (2002-02-14), pages 491 - 496, XP002967410, ISSN: 0028-4793
WELCH P G ET AL: "Safety and immunogenicity of staphylococcus aureus type 5 capsular polysaccharide-pseudomonas aeruginosa recombinant exoprotein A conjugate vaccine in patients on hemodialysis", JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, WILLIAMS AND WILKINS, BALTIMORE, MD, US, vol. 7, 1996, pages 247 - 253, XP002967409, ISSN: 1046-6673
KONADU E ET AL: "Preparation, characterization, and immunological properties in mice of Escherichia coli O157 O-specific polysaccharide-protein conjugate vaccines", INFECTION AND IMMUNITY, AMERICAN SOCIETY FOR MICROBIOLOGY. WASHINGTON, US, vol. 62, no. 11, November 1994 (1994-11-01), pages 5048 - 5054, XP002912809, ISSN: 0019-9567
DEVI S J N ET AL: "Antibodies to poly[(2->8)-[alpha]-N-acetylneuraminic acid] and poly[(2->9)-[alpha]-N-acetylneuraminic acid] are elicited by immunization of mice with Escherichia coli K92 conjugates: Potential vaccines for groups B and C meningococci and E. coli K1", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 88, no. 16, 15 August 1991 (1991-08-15), pages 7175 - 7179, XP002044636, ISSN: 0027-8424
JOSEFSSON E ET AL: "PROTECTION AGAINST STAPHYLOCOCCUS AUREUS ARTHRITIS BY VACCINATION WITH CLUMPING FACTOR A, A NOVEL VIRULENCE DETERMINANT", IMMUNOLOGY LETTERS, AMSTERDAM, NL, vol. 73, no. 2/3, September 2000 (2000-09-01), pages 153 - 154, XP009029019, ISSN: 0165-2478
JOSEFSSON E ET AL: "Protection against experimental Staphylococcus aureus arthritis by vaccination with clumping factor A, a novel virulence determinant", JOURNAL OF INFECTIOUS DISEASES, CHICAGO, IL, US, vol. 184, no. 12, 15 December 2001 (2001-12-15), pages 1572 - 1580, XP009028976, ISSN: 0022-1899
CASOLINI F ET AL: "Antibody response to fibronectin-binding adhesin FnbpA in patients with Staphylococcus aureus infections", INFECTION AND IMMUNITY, AMERICAN SOCIETY FOR MICROBIOLOGY. WASHINGTON, US, vol. 66, no. 11, November 1998 (1998-11-01), pages 5433 - 5442, XP002222372, ISSN: 0019-9567
MAMO W ET AL: "VACCINATION WITH STAPHYLOCOCCUS AUREUS FIBRINOGEN BINDING PROTEINS (FGBPS) REDUCES COLONISATION OF S. AUREUS IN A MOUSE MASTITIS MODEL", FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY, ELSEVIER SCIENCE B.V., AMSTERDAM, NL, vol. 10, no. 1, 1 November 1994 (1994-11-01), pages 47 - 54, XP000619735, ISSN: 0928-8244
FATTOM A ET AL: "Effect of conjugation methodology, carrier protein, and adjuvants on the immune response to Staphylococcus aureus capsular polysaccharides", VACCINE, BUTTERWORTH SCIENTIFIC. GUILDFORD, GB, vol. 13, no. 14, 1 October 1995 (1995-10-01), pages 1288 - 1293, XP004057429, ISSN: 0264-410X
PARK HEE-MYUNG ET AL: "Immunogenicity of alpha-toxin, capsular polysaccharide (CPS) and recombinant fibronectin-binding protein (r-FnBP) of Staphylococcus aureus in rabbit", JOURNAL OF VETERINARY MEDICAL SCIENCE, vol. 61, no. 9, September 1999 (1999-09-01), pages 995 - 1000, XP002293941, ISSN: 0916-7250
HAN HONG RYUL ET AL: "Determination of alpha-toxin antibodies against Staphylococcus aureus and phagocytic ability postimmunization in rabbits", BOVINE PRACTITIONER, no. 32 PART 1, January 1998 (1998-01-01), pages 14 - 17, XP008034262, ISSN: 0524-1685 0524-1685
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