POLYVALENT, PRIMARY HIV-1 GLYCOPROTEIN DNA VACCINES AND VACCINATION METHODS

WIPO Patent Application WO2004050856

A3

Polyvalent, primary isolate nucleic acid compositions for inducing an immune response against HIV is disclosed. The compositions and methods described herein are for the use of a DNA composition that encodes one or more different HIV envelope glycoproteins. The DNA composition can encode an HIV Gag protein. The DNAs encoding one or more HIV proteins are a combination of different nucleic acids, such as DNA plasmids, generated from primary isolate DNA of different HIV major group genetic clades and/or different proteins. HIV protein compositions for inducing an immune response against HIV are disclosed. Methods for using the protein compositions as boosts following administration of the DNA compositions are provided.

LU SHAN (US)
WANG SHIXIA (US)
PAL RANAJIT (US)
KALYANARAMAN V S (US)
WHITNEY STEPHEN CHARLES (US)
KEEN TIM (US)
NAIR BALACHANDRAN C (US)
MARKHAM PHILLIP (US)

PCT/US2003/038640

March 24, 2005

December 03, 2003

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UNIV MASSACHUSETTS (US)
ADVANCED BIOSCIENCE LAB INC (US)
LU SHAN (US)
WANG SHIXIA (US)
PAL RANAJIT (US)
KALYANARAMAN V S (US)
WHITNEY STEPHEN CHARLES (US)
KEEN TIM (US)
NAIR BALACHANDRAN C (US)
MARKHAM PHILLIP (US)

A61K39/21; A61K39/295; C07K14/16; A61K39/00; (IPC1-7): C07H21/04; A61K39/21

US5420030A	1995-05-30
US5830876A	1998-11-03
US6139843A	2000-10-31
US6090392A	2000-07-18

NYAMBI P.N. ET AL.: "Immunoreactivity of intact virions of human immunodeficiency virus type 1 (HIV-1) reveals the existance of fewre HIV-1 immunotypes than genotypes", J. VIROL., vol. 74, no. 22, November 2000 (2000-11-01), pages 10670 - 10680, XP003012221

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