Title:
POORLY SOLUBLE COMPLEX OR SOLVATE THEREOF, PHARMACEUTICAL COMPOSITION, AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/177232
Kind Code:
A1
Abstract:
The present invention provides a complex of formula (I) or a solvate thereof, wherein n is 1 to 4. The present invention also provides a pharmaceutical composition and an application of the pharmaceutical composition in preventing or treating pain of, during, or after surgery. According to the technical solution of the present invention, provided is a drug with a simple production process and being capable of long-term sustained release of a local anesthetic in the body, and the local anesthetic can be continuously released for at least three days. The drug extends an analgesic effect on pain after surgery, is convenient to use for doctors and patients, and has good compliance.
Inventors:
ZHANG SHANCHUN (CN)
WANG YIHUA (CN)
PENG JIASHI (CN)
CHENG KAISHENG (CN)
WANG XIAO (CN)
GAO SHU (CN)
SUN HONGZHANG (CN)
LU XIAORONG (CN)
WANG YIHUA (CN)
PENG JIASHI (CN)
CHENG KAISHENG (CN)
WANG XIAO (CN)
GAO SHU (CN)
SUN HONGZHANG (CN)
LU XIAORONG (CN)
Application Number:
PCT/CN2018/080424
Publication Date:
October 04, 2018
Filing Date:
March 26, 2018
Export Citation:
Assignee:
HEFEI COSOURCE PHARMACEUTICALS INC (CN)
HEFEI BLOOMING DRUG SAFETY EVALUATION CO LTD (CN)
HEFEI BLOOMING DRUG SAFETY EVALUATION CO LTD (CN)
International Classes:
C07D211/60; A61K31/245; A61K31/445; A61P25/04; C07C65/11
Foreign References:
| CN104370934A | 2015-02-25 |
Other References:
OSTERGAARD ET AL.: "Bupivacaine Salts of Diflunisal and Other Aromatic Hydro-Xycarboxylic Acids: Aqueous Solubility and Release Characteristics from Solutions and Suspensions Using a Rotating Dialysis Cell Model", EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 26, 31 December 2005 (2005-12-31), pages 280 - 287, XP027803692
NAOMI, I. ET AL.: "Dissolution of Bupicacaine 3-Hydroxy-2-Naphthoate into Phosphate Buffers", J. PHARM. PHARMACOL., vol. 31, 24 January 1979 (1979-01-24), pages 622 - 626, XP055577331
NAOMI, I. ET AL.: "Dissolution of Bupicacaine 3-Hydroxy-2-Naphthoate into Phosphate Buffers", J. PHARM. PHARMACOL., vol. 31, 24 January 1979 (1979-01-24), pages 622 - 626, XP055577331
Attorney, Agent or Firm:
CHINA SCIENCE PATENT & TRADEMARK AGENT LTD. (CN)
Download PDF:
Previous Patent: MEDICAL USE OF ARTEMISININ DERIVATIVE FOR TREATING INFLAMMATORY BOWEL DISEASE
Next Patent: VOICE FUNCTION CONTROL METHOD AND APPARATUS
Next Patent: VOICE FUNCTION CONTROL METHOD AND APPARATUS