Title:
POROUS MICROSPHERE INCLUDING MUSSEL ADHESIVE PROTEIN, AND METHOD FOR MANUFACTURING SAME
Document Type and Number:
WIPO Patent Application WO/2018/182278
Kind Code:
A1
Abstract:
The present invention relates to a porous microsphere including a mussel adhesive protein, and a method for manufacturing same. A porous microsphere including a mussel adhesive protein according to the present invention can be injected into a living body in a minimally invasive manner through a syringe, and thus, as a cell delivery vehicle, can efficiently deliver stem cells for treatment to areas of tissue damage. Moreover, the porous microsphere is widely applicable as a tissue engineering scaffold capable of being appropriately applied according to the size of a tissue defect area, or as a drug delivery vehicle and the like.
Inventors:
CHA HYUNG JOON (KR)
KIM DONG PYO (KR)
JO YUN KEE (KR)
MIN KYOUNG IK (KR)
KIM DONG PYO (KR)
JO YUN KEE (KR)
MIN KYOUNG IK (KR)
Application Number:
PCT/KR2018/003585
Publication Date:
October 04, 2018
Filing Date:
March 27, 2018
Export Citation:
Assignee:
POSTECH ACAD IND FOUND (KR)
International Classes:
C07K14/435; A61K47/64; A61L27/22; C12N15/63
Foreign References:
| KR20160037413A | 2016-04-06 | |||
| KR20120013626A | 2012-02-15 | |||
| KR20110007672A | 2011-01-25 | |||
| KR20130021951A | 2013-03-06 |
Other References:
BRUBAKER, C. E.: "Enzymatically Degradable Mussel-Inspired Adhesive Hydrogel", BIOMACROMOLECULES, 2011, pages 4326 - 4334, XP055062324, DOI: doi:10.1021/bm201261d
LEE, B. P.: "Synthesis of 3, 4-dihydroxyphenylalanine (DOPA) containing monomers and their co-polymerization with PEG-diacrylate to form hydrogels", JOURNAL OF BIOMATERIALS SCIENCE , POLYMER EDITION, vol. 15, no. 4, 2004, pages 449 - 464, XP009075020
YANG, Y.: "Development of highly porous large PLGA microparticles for pulmonary drug delivery", BIOMATERIALS, 2009, pages 1947 - 1953, XP025917833, DOI: doi:10.1016/j.biomaterials.2008.12.044
KIM, J. H. ET AL.: "Droplet microfluidics for producing functional microparticles", LANGMUIR, vol. 30, no. 6, 21 October 2013 (2013-10-21), pages 1473 - 1488, XP055612542
JO, Y. K.: "Mussel protein-based sticky porous microspheres as an injectable stem cell carrier with vascularization capacity", October 2017 (2017-10-01), pages 11 - 13
LEE, B. P.: "Synthesis of 3, 4-dihydroxyphenylalanine (DOPA) containing monomers and their co-polymerization with PEG-diacrylate to form hydrogels", JOURNAL OF BIOMATERIALS SCIENCE , POLYMER EDITION, vol. 15, no. 4, 2004, pages 449 - 464, XP009075020
YANG, Y.: "Development of highly porous large PLGA microparticles for pulmonary drug delivery", BIOMATERIALS, 2009, pages 1947 - 1953, XP025917833, DOI: doi:10.1016/j.biomaterials.2008.12.044
KIM, J. H. ET AL.: "Droplet microfluidics for producing functional microparticles", LANGMUIR, vol. 30, no. 6, 21 October 2013 (2013-10-21), pages 1473 - 1488, XP055612542
JO, Y. K.: "Mussel protein-based sticky porous microspheres as an injectable stem cell carrier with vascularization capacity", October 2017 (2017-10-01), pages 11 - 13
Attorney, Agent or Firm:
KIM, Soon Woong (KR)
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