POROUS RESIN USED TO SOLID PHASE SYNTHESIS AND PREPARATION METHOD THEREFOR

Title:

POROUS RESIN USED TO SOLID PHASE SYNTHESIS AND PREPARATION METHOD THEREFOR

Document Type and Number:

WIPO Patent Application WO/2022/110560

Kind Code:

A1

Abstract:

A porous resin used to solid phase synthesis and a preparation method therefor, specifically being a porous resin having functional groups being an amino group or a hydroxyl group and a preparation method therefor. Using an olefin compound containing two cyano groups as a modified monomer, using a high internal phase emulsion as a pore-foaming agent, and performing suspension polymerization to prepare the porous resin. And then functionalizing the porous resin to obtain the porous resin having functional groups being an amino group or a hydroxyl group. Different from the existing preparation method, the modified monomer can make the distribution of the functional groups more uniform, and make the swelling degrees of the porous resin in different solvents close. The high internal phase emulsion pore-foaming agent can make the pore size distribution of the carrier narrower. The porous resin can be used as a solid phase synthesis carrier to prepare an oligonucleotide, and the use of the carrier is beneficial for improving the yield and purity of the oligonucleotide.

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WO/2007/125543	CONTINUOUS NEUTRALIZER MIXER REACTOR AND A CONTINUOUS PROCESS FOR QUENCHING CHLORINATION REACTION MIXTURE IN PRODUCTION OF CHLORINATED SUCROSE
WO/1987/005936	PROCESS FOR THE MANUFACTURE OF OLIGOSACCHARIDES
WO/2020/001166	GLYCOSIDE COMPOUND AND PREPARATION METHOD THEREFOR, COMPOSITION, APPLICATION, AND INTERMEDIATE

Inventors:

WANG CHAOYANG (CN)
ZHANG CHENG (CN)
WU DAN (CN)
ZHAO WEIJIE (CN)
LI YANJUN (CN)
LIU QIONG (CN)
KOU XIAOKANG (CN)

Application Number:

PCT/CN2021/077663

Publication Date:

June 02, 2022

Filing Date:

February 24, 2021

Export Citation:

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Assignee:

SUNRESIN NEW MAT CO LTD (CN)
SUNRESIN NEW MAT CO LTD GAOLING (CN)

International Classes:

C07H1/00; C08F212/08; C07H21/00; C08F212/12; C08F212/14; C08F212/36; C08F222/34; C08J9/28; C08J9/36

Domestic Patent References:

WO2006029023A2

2006-03-16

Foreign References:

CN101076546A	2007-11-21
CN101613430A	2009-12-30
CN102020813A	2011-04-20
CN103890085A	2014-06-25
CN103881016A	2014-06-25
US8592542B2	2013-11-26
US8653152B2	2014-02-18
CN201210562165A	2012-12-20

Other References:

XIE FEIFEI, HU WEI, DING LEI, TIAN KE, WU ZHENGCHEN, LI LEI: "Synthesis of microporous organic polymers via radical polymerization of fumaronitrile with divinylbenzene", POLYMER CHEMISTRY, vol. 8, no. 39, 1 January 2017 (2017-01-01), pages 6106 - 6111, XP055935319, ISSN: 1759-9954, DOI: 10.1039/C7PY01240C
See also references of EP 4177281A4

Attorney, Agent or Firm:

SUNSHINE INTELLECTUAL PROPERTY INTERNATIONAL CO., LTD. (CN)

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