Title:
POROUS SCAFFOLD PROVIDED WITH SURFACE ORIENTATION FUNCTION MODIFICATION COATING AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2019/033646
Kind Code:
A1
Abstract:
Provided in the invention are a porous scaffold provided with a surface orientation function modification coating and a preparation method therefor. The surface of the porous scaffold material structure is coated with a polydopamine coating structure, and a functional component structure layer capable of releasing drug molecules or biomolecules with bioactive function/action in a biological fluid environment is grafted in a modular way to a hydroxyl and/or amino part on the surface of the polydopamine coating structure. During preparation, firstly, the polydopamine coating is deposited on the surface of the porous scaffold; then, hydroxyl groups and/or amino groups in the surface of the scaffold material and corresponding functional components are subjected to azidation or alkynylation respectively; finally, a graft structure layer of the functional components is formed on the surface of the polydopamine coating of the porous scaffold material structure after specific azide-alkynyl modular grafting. The grafting efficiency of the functional components on the surface of the porous scaffold material is high, the grafting structure layer is firmer, the application field of the scaffold material is broadened, more function selections are provided for the scaffold material, and novel means are particularly provided for bone repair, blood vessel therapy, cancer therapy and the like.
Inventors:
ZUO YI (CN)
HU FU (CN)
LI YUBAO (CN)
CHEN JIE (CN)
ZOU QIN (CN)
LI JIDONG (CN)
HU FU (CN)
LI YUBAO (CN)
CHEN JIE (CN)
ZOU QIN (CN)
LI JIDONG (CN)
Application Number:
PCT/CN2017/116211
Publication Date:
February 21, 2019
Filing Date:
December 14, 2017
Export Citation:
Assignee:
SI CHUAN UNIV (CN)
International Classes:
A61L27/34; A61L27/18
Domestic Patent References:
| WO2009047346A1 | 2009-04-16 |
Foreign References:
| CN107335093A | 2017-11-10 | |||
| CN102813963A | 2012-12-12 | |||
| CN104356345A | 2015-02-18 | |||
| CN106983912A | 2017-07-28 | |||
| CN1453354A | 2003-11-05 |
Attorney, Agent or Firm:
CHENGDU HONGQIAO PATENT LAW OFFICE (CN)
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