Title:
PORPHYRIN COMPOUND
Document Type and Number:
WIPO Patent Application WO/2011/034183
Kind Code:
A1
Abstract:
Disclosed is a novel porphyrin metal complex which is safe in vivo and satisfies requirements for relaxation ability, cancer cell selectivity, organ selectivity and the like. The porphyrin metal complex is able to be applied to an MRI contrast medium. Also disclosed is a molecular aggregate of the porphyrin metal complex.
Specifically disclosed is a porphyrin metal complex represented by formula (1).
(In the formula, R1-R12 each represents a hydrogen atom, a halogen atom, a nitro group, a cyano group, a sulfonyl group, a hydroxy group, an amino group, a carboxyl group, an optionally substituted alkyl group having 1-10 carbon atoms, a cycloalkyl group having 3-6 carbon atoms, an alkoxy group having 1-6 carbon atoms, an optionally substituted phenyl group, or a group selected from the group consisting of oligoethylene glycol methyl ether groups represented by formula (2) (wherein n represents a number of 1-10), (provided that at least one of the R1-R12 represents a group represented by formula (2)); and M represents a divalent metal atom or a trivalent to pentavalent metal atom which may have a substituent atom or a substituent group.)
Inventors:
KOGA NOBORU (JP)
KARASAWA SATORU (JP)
HAYASHI HIROYUKI (JP)
OKUBO KENGO (JP)
KARASAWA SATORU (JP)
HAYASHI HIROYUKI (JP)
OKUBO KENGO (JP)
Application Number:
PCT/JP2010/066247
Publication Date:
March 24, 2011
Filing Date:
September 17, 2010
Export Citation:
Assignee:
UNIV KYUSHU (JP)
NISSAN CHEMICAL IND LTD (JP)
KOGA NOBORU (JP)
KARASAWA SATORU (JP)
HAYASHI HIROYUKI (JP)
OKUBO KENGO (JP)
NISSAN CHEMICAL IND LTD (JP)
KOGA NOBORU (JP)
KARASAWA SATORU (JP)
HAYASHI HIROYUKI (JP)
OKUBO KENGO (JP)
International Classes:
C07D487/22; A61K49/00; C07F13/00; C07F15/02; C07F15/06
Domestic Patent References:
| WO2008095366A1 | 2008-08-14 |
Foreign References:
| CN101070323A | 2007-11-14 | |||
| JP2009094366A | 2009-04-30 | |||
| JPH09249670A | 1997-09-22 |
Other References:
SAKURAI T. ET AL: "Prominent electron transport property observed for triply fused metalloporphyrin dimer: directed columnar liquid crystalline assembly by amphiphilic molecular design", J. AM. CHEM. SOC., vol. 130, 2008, pages 13812 - 13813
JUNG S.H. ET AL: "Supramolecular functionalization of single-walled carbon nanotubes with unchanged water soluble porphyrins", J. PORPHYRINS PHTHALOCYANINES, vol. 12, 2008, pages 109 - 115
JUNG S.H. ET AL: "Supramolecular functionalization of single-walled carbon nanotubes with unchanged water soluble porphyrins", J. PORPHYRINS PHTHALOCYANINES, vol. 12, 2008, pages 109 - 115
Attorney, Agent or Firm:
HANABUSA, Tsuneo et al. (JP)
Sepal Tsuneo (JP)
Sepal Tsuneo (JP)
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