Title:
PORPHYRIN DERIVATIVES, PREPARATION METHODS AND THE USES AS SMALL MOLECULAR ANTIOXIDANT THEREOF
Document Type and Number:
WIPO Patent Application WO/2008/095366
Kind Code:
A1
Abstract:
A porphyrin derivative and its pharmaceutical acceptable salt and its preparation
method. The said porphyrin derivative is M-5,10,15,20-tetra[3-ethylene polyol
monomethyl ether-substituted -phenyl]porphyrin, in which M is one of Fe, Mn,
Co, Ni, Cu, Zn, Sn, Cr, V and Pt metal ions. The said porphyrin derivative can be
used as small molecular antioxidant for regulating the concentration of peroxide
between cells of human body or in cell, protecting the body to avoid the damage
from peroxy radical or from other peroxide derived from peroxy radical, preventing
or treating the diseases caused by the peroxide.
Inventors:
GONG XIANCHANG (CN)
HU TAIYOU (CN)
DONG CHANGZHI (CN)
GUO TIANSHUN (CN)
SONG CAIYAN (CN)
DENG ZHIPING (CN)
HU TAIYOU (CN)
DONG CHANGZHI (CN)
GUO TIANSHUN (CN)
SONG CAIYAN (CN)
DENG ZHIPING (CN)
Application Number:
PCT/CN2007/002970
Publication Date:
August 14, 2008
Filing Date:
October 17, 2007
Export Citation:
Assignee:
JINAN SAIWEN PHARMTECHNOLOGY I (CN)
GONG XIANCHANG (CN)
HU TAIYOU (CN)
DONG CHANGZHI (CN)
GUO TIANSHUN (CN)
SONG CAIYAN (CN)
DENG ZHIPING (CN)
GONG XIANCHANG (CN)
HU TAIYOU (CN)
DONG CHANGZHI (CN)
GUO TIANSHUN (CN)
SONG CAIYAN (CN)
DENG ZHIPING (CN)
International Classes:
C07D487/22; A61K31/409; A61K31/555; A61P3/10; A61P7/02; A61P17/18; A61P19/02; A61P25/16; A61P31/18; A61P35/00; A61P39/06
Domestic Patent References:
| WO1995031219A1 | 1995-11-23 |
Foreign References:
| CN1450066A | 2003-10-22 | |||
| EP1279676A1 | 2003-01-29 |
Other References:
SESSLER J.L. ET AL.: "Water soluble sapphyrins: potential fluorescent phosphate anion sensors", ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 1, no. 22, 2003, pages 4113 - 4123
BANERJEE S. ET AL.: "A novel 186/188Re]-labelled porphyrin for targeted radiotherapy", NUCLEAR MEDICINE COMMUNICATIONS, vol. 22, no. 10, 2001, pages 1101 - 1107
BANERJEE S. ET AL.: "A novel 186/188Re]-labelled porphyrin for targeted radiotherapy", NUCLEAR MEDICINE COMMUNICATIONS, vol. 22, no. 10, 2001, pages 1101 - 1107
Attorney, Agent or Firm:
CN-KNOWHOW INTELLECTUAL PROPERTY AGENT LIMITED (Fortune International CenterNo. 17 Daliushu Road, Beijing 1, CN)
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