Title:
POTASSIUM CHANNEL OPENERS
Document Type and Number:
WIPO Patent Application WO2001009096
Kind Code:
A3
Abstract:
Compounds of formula (I), are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.
Inventors:
ALTENBACH ROBERT J
BAI HAO
BRIONI JORGE D
CARROLL WILLIAM A
GOPALAKRISHNAN MURALI
GREGG ROBERT J
HOLLADAY MARK W
HUANG PEGGY P
KINCAID JOHN F
KORT MICHAEL E
KYM PHILIP R
LYNCH JOHN K
PEREZ-MEDRANO ARTURO
ZHANG HENRY Q
BAI HAO
BRIONI JORGE D
CARROLL WILLIAM A
GOPALAKRISHNAN MURALI
GREGG ROBERT J
HOLLADAY MARK W
HUANG PEGGY P
KINCAID JOHN F
KORT MICHAEL E
KYM PHILIP R
LYNCH JOHN K
PEREZ-MEDRANO ARTURO
ZHANG HENRY Q
Application Number:
PCT/US2000/021054
Publication Date:
August 16, 2001
Filing Date:
August 02, 2000
Export Citation:
Assignee:
ABBOTT LAB (US)
International Classes:
C07D249/18; A61K31/166; A61K31/17; A61K31/417; A61K31/4192; A61K31/44; A61K31/4406; A61K31/47; A61P1/00; A61P9/00; A61P9/10; A61P11/06; A61P13/02; A61P13/08; A61P13/10; A61P15/00; A61P15/10; A61P17/14; A61P25/00; A61P25/02; A61P25/06; A61P25/08; C07C233/78; C07C233/83; C07C271/22; C07C275/28; C07C275/30; C07C275/54; C07C279/22; C07C279/28; C07C279/36; C07C335/16; C07C335/18; C07C335/26; C07D209/08; C07D213/74; C07D213/75; C07D215/38; C07D233/02; C07D233/42; C07D235/06; C07D239/42; C07D401/04; C07D401/12; C07D405/12; C07D407/12; (IPC1-7): C07D213/74; C07C335/18; C07C335/16; C07C279/28; C07C279/30; C07D209/08; C07D235/06; C07D401/12; C07D239/42; C07D401/04; C07D233/42; C07D407/12; C07C275/30; C07D215/38; A61K31/47; A61K31/44; A61K31/17; A61K31/155
Foreign References:
| EP0503627A1 | 1992-09-16 | |||
| EP0501797A1 | 1992-09-02 | |||
| EP0381504A2 | 1990-08-08 | |||
| FR2023940A1 | 1970-08-21 | |||
| FR2340927A1 | 1977-09-09 |
Other References:
FENG, LEI ET AL: "Selective fluorescence derivatization and capillary electrophoretic separation of amidated amino acids", J. CHROMATOGR., A (1999), 832(1 + 2), 211-224, XP004156180
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; EYADA, H. A.: "Synthesis of some 4,5,6,7-tetrachlorophthalimido containing benzoxazole, benzimidazole, benzoxazine, and carbamate moieties", XP002151933, retrieved from STN Database accession no. 124:289398
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; MOHAMED, Y. A.: "Synthesis and reactions of some new 5,6-dichlorophthalimidoacetic acid derivatives", XP002151934, retrieved from STN Database accession no. 118:38720
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; AMMAR, Y. V. ET AL: "Some reactions with the unusual amino acid DL-C-phenylglycine", XP002151935, retrieved from STN Database accession no. 117:131520
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; ESSAWY, SAMY A. ET AL: "Synthesis and reactions of phthalimido aliphatic acid azides", XP002151936, retrieved from STN Database accession no. 116:173943
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; VINOGRADOVA, T. K. ET AL: "Intramolecular cyclization and annulation in dehydrochlorination of products of addition of amines to carboxylic acid N-(1-isothiocyanato-2,2-dichloroethyl)amides", XP002151937, retrieved from STN Database accession no. 114:61984
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; BOYER, JOSEPH H. ET AL: "Alkylation of nitrocyanamide. A new synthesis of isocyanates", XP002151938, retrieved from STN Database accession no. 110:94646
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; ALY, N. F., MRS. ET AL: "Acid azides: part IX - synthesis and reactions of phthalimidoacetic acid azide and its derivatives", XP002151939, retrieved from STN Database accession no. 101:110675
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; TIWARI, S. S. ET AL: "Synthesis of possible antiparkinsonian compounds. VIII. Synthesis of N1-(nicotinamidomethyl)-N3-arylureas and N1-[2-(o- methylbenzimidazolyl)salicylamidomethyl]-N3-arylureas", XP002151940, retrieved from STN Database accession no. 84:17225
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; BOEHME, H. ET AL: "N-(.alpha.-Haloalkyl)carboxamides. 20. Imidomethyl thiocyanates and isothiocyanates", XP002151941, retrieved from STN Database accession no. 82:3924
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; DRACH, B. S. ET AL: "Reaction of N-chloromethyl acid amides with silver isocyanate and potassium isothiocyanate", XP002151942, retrieved from STN Database accession no. 78:15735
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; MOFFATT, J. G. ET AL: "Carbodiimide-sulfoxide reactions. XI. Reactions of carboxylic acids, hydroxamic acids, and amides", XP002151943, retrieved from STN Database accession no. 76:3528
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; DRACH, B. S. ET AL: "N-(1,2,2,2-Tetrachloroethyl) amides", XP002151944, retrieved from STN Database accession no. 75:63069
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; FEST, CHRISTA ET AL: "Pesticidal fluoroacetylaminotrichloromethylmethylthiocarbamic acid esters and ureas", XP002151945, retrieved from STN Database accession no. 73:130653
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; EYADA, H. A.: "Synthesis of some 4,5,6,7-tetrachlorophthalimido containing benzoxazole, benzimidazole, benzoxazine, and carbamate moieties", XP002151933, retrieved from STN Database accession no. 124:289398
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; MOHAMED, Y. A.: "Synthesis and reactions of some new 5,6-dichlorophthalimidoacetic acid derivatives", XP002151934, retrieved from STN Database accession no. 118:38720
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; AMMAR, Y. V. ET AL: "Some reactions with the unusual amino acid DL-C-phenylglycine", XP002151935, retrieved from STN Database accession no. 117:131520
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; ESSAWY, SAMY A. ET AL: "Synthesis and reactions of phthalimido aliphatic acid azides", XP002151936, retrieved from STN Database accession no. 116:173943
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; VINOGRADOVA, T. K. ET AL: "Intramolecular cyclization and annulation in dehydrochlorination of products of addition of amines to carboxylic acid N-(1-isothiocyanato-2,2-dichloroethyl)amides", XP002151937, retrieved from STN Database accession no. 114:61984
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; BOYER, JOSEPH H. ET AL: "Alkylation of nitrocyanamide. A new synthesis of isocyanates", XP002151938, retrieved from STN Database accession no. 110:94646
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; ALY, N. F., MRS. ET AL: "Acid azides: part IX - synthesis and reactions of phthalimidoacetic acid azide and its derivatives", XP002151939, retrieved from STN Database accession no. 101:110675
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; TIWARI, S. S. ET AL: "Synthesis of possible antiparkinsonian compounds. VIII. Synthesis of N1-(nicotinamidomethyl)-N3-arylureas and N1-[2-(o- methylbenzimidazolyl)salicylamidomethyl]-N3-arylureas", XP002151940, retrieved from STN Database accession no. 84:17225
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; BOEHME, H. ET AL: "N-(.alpha.-Haloalkyl)carboxamides. 20. Imidomethyl thiocyanates and isothiocyanates", XP002151941, retrieved from STN Database accession no. 82:3924
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; DRACH, B. S. ET AL: "Reaction of N-chloromethyl acid amides with silver isocyanate and potassium isothiocyanate", XP002151942, retrieved from STN Database accession no. 78:15735
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; MOFFATT, J. G. ET AL: "Carbodiimide-sulfoxide reactions. XI. Reactions of carboxylic acids, hydroxamic acids, and amides", XP002151943, retrieved from STN Database accession no. 76:3528
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; DRACH, B. S. ET AL: "N-(1,2,2,2-Tetrachloroethyl) amides", XP002151944, retrieved from STN Database accession no. 75:63069
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; FEST, CHRISTA ET AL: "Pesticidal fluoroacetylaminotrichloromethylmethylthiocarbamic acid esters and ureas", XP002151945, retrieved from STN Database accession no. 73:130653
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