Title:
POTENT AND SELECTIVE INHIBITORS OF MONOAMINE TRANSPORTERS; METHOD OF MAKING; AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2014/138518
Kind Code:
A3
Abstract:
Disclosed herein are bisarylmethylthioacetamides and bisarylmethylthioethylamines useful as inhibitors of monoamine transporters. The compounds are potent and/or selective inhibitors of dopamine (DA), serotonin (5-HT), and/or norepinephrine (NE) reuptake via their respective transporters, DAT, SERT and NET. Also disclosed are methods for eliciting a wake-promoting or cognitive or attention enhancing effect and for treating substance use disorders, attention deficit (hyperactivity) disorder, depressive disorders, bipolar disorder or other neuropsychiatric disorders sleep disorders or cognitive impairment using the compounds.
Inventors:
NEWMAN AMY HAUCK (US)
OKUNOLA-BAKARE OLUYOMI M (US)
CAO JIANJING (US)
OKUNOLA-BAKARE OLUYOMI M (US)
CAO JIANJING (US)
Application Number:
PCT/US2014/021514
Publication Date:
November 06, 2014
Filing Date:
March 07, 2014
Export Citation:
Assignee:
US HEALTH (US)
International Classes:
C07C317/44; A61K31/255; A61P25/00
Domestic Patent References:
| WO2003066035A2 | 2003-08-14 |
Foreign References:
| US4177290A | 1979-12-04 | |||
| US4927855A | 1990-05-22 | |||
| EP0528172A1 | 1993-02-24 | |||
| FR2601673A2 | 1988-01-22 |
Other References:
JIANJING CAO ET AL: "SARs at the Monoamine Transporters for a Novel Series of Modafinil Analogues", ACS MEDICINAL CHEMISTRY LETTERS, AMERICAN CHEMICAL SOCIETY, US, vol. 2, no. 1, 13 January 2011 (2011-01-13), pages 48 - 52, XP002645183, ISSN: 1948-5875, [retrieved on 20101018], DOI: 10.1021/ML1002025
LOLAND CLAUS J ET AL: "R-modafinil (armodafinil): a unique dopamine uptake inhibitor and potential medication for psychostimulant abuse", BIOLOGICAL PSYCHIATRY, USA, vol. 72, no. 5, 1 September 2012 (2012-09-01), pages 405 - 413, XP009163447, ISSN: 1873-2402
ZHANG ET AL: "Synthesis and biological evaluation of (R)-N-(diarylmethylthio/sulfinyl)ethyl/propyl-piperidine-3-carboxylic acid hydrochlorides as novel GABA uptake inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, AMSTERDAM, NL, vol. 17, no. 13, 1 July 2007 (2007-07-01), pages 3769 - 3773, XP022114579, ISSN: 0960-894X, DOI: 10.1016/J.BMCL.2007.04.010
LOLAND CLAUS J ET AL: "R-modafinil (armodafinil): a unique dopamine uptake inhibitor and potential medication for psychostimulant abuse", BIOLOGICAL PSYCHIATRY, USA, vol. 72, no. 5, 1 September 2012 (2012-09-01), pages 405 - 413, XP009163447, ISSN: 1873-2402
ZHANG ET AL: "Synthesis and biological evaluation of (R)-N-(diarylmethylthio/sulfinyl)ethyl/propyl-piperidine-3-carboxylic acid hydrochlorides as novel GABA uptake inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, AMSTERDAM, NL, vol. 17, no. 13, 1 July 2007 (2007-07-01), pages 3769 - 3773, XP022114579, ISSN: 0960-894X, DOI: 10.1016/J.BMCL.2007.04.010
Attorney, Agent or Firm:
PELLETIER, Roberta, L. (20 Church Street 22nd Floo, Hartford CT, US)
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