Title:
POTENT AND SELECTIVE NEURONAL NITRIC OXIDE SYNTHASE INHIBITORS WITH IMPROVED MEMBRANE PERMEABILITY
Document Type and Number:
WIPO Patent Application WO/2010/085749
Kind Code:
A3
Abstract:
Compounds and related compositions and methods as can be used to inhibit neuronal nitric oxide synthase and as can be employed in the treatment of various neurodegenerative diseases.
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Inventors:
SILVERMAN RICHARD B (US)
XUE FENGTIAN (US)
XUE FENGTIAN (US)
Application Number:
PCT/US2010/021989
Publication Date:
March 31, 2011
Filing Date:
January 25, 2010
Export Citation:
Assignee:
UNIV NORTHWESTERN (US)
SILVERMAN RICHARD B (US)
XUE FENGTIAN (US)
SILVERMAN RICHARD B (US)
XUE FENGTIAN (US)
International Classes:
C07D403/06; A61K31/4355; A61P25/28; C07D403/14
Domestic Patent References:
| WO2008036294A2 | 2008-03-27 |
Foreign References:
| US20080108814A1 | 2008-05-08 | |||
| US20080176907A1 | 2008-07-24 | |||
| US20050107369A1 | 2005-05-19 |
Other References:
JI, HAIRAO ET AL.: "Discovery of Highly Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase by Fragment Hopping.", J. MED. CHEM., vol. 52, 2009, pages 779 - 797
BERTRAND LE BOURDONEC ET AL.: "Discovery of a series of aminopiperidines as novel iNOS inhibitors.", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 18, 2008, pages 336 - 343, XP022410911, DOI: doi:10.1016/j.bmcl.2007.10.073
HAH, JUNG-MI ET AL.: "Aromatic Reduced Amide Bond Peptidomimetics as Selective Inhibitors of Neuronal Nitric Oxide Synthase.", J. MED. CHEM., vol. 46, 2003, pages 1661 - 1669
BERTRAND LE BOURDONEC ET AL.: "Discovery of a series of aminopiperidines as novel iNOS inhibitors.", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 18, 2008, pages 336 - 343, XP022410911, DOI: doi:10.1016/j.bmcl.2007.10.073
HAH, JUNG-MI ET AL.: "Aromatic Reduced Amide Bond Peptidomimetics as Selective Inhibitors of Neuronal Nitric Oxide Synthase.", J. MED. CHEM., vol. 46, 2003, pages 1661 - 1669
Attorney, Agent or Firm:
DEKRUIF, Rodney, D. et al. (1000 North Water Street Suite 170, Milwaukee WI, US)
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