Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
POTENT SOFT ANTI-INFLAMMATORY CORTICOSTEROID COMPOUNDS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/232007
Kind Code:
A8
Abstract:
Potent soft corticosteroid pharmaceutical compositions comprising them and method for use as anti-inflammatory agents. Also, a method for softening fluticasone propionate and similar corticosteroids to arrive at potent but safer alternatives. The compound S-fluoromethyl 17α-dichloroacetoxy-6α,9α-difluoro-11β-hydroxy-16a- methyl-3-oxoandrosta-1,4-diene-17β-carbothioate, which is equally potent to but safer than fluticasone, is among those provided. Another compound of particular interest is 2-hydroxyethyl 17α-dichloroacetoxy-6α,9α-difluoro-11β-hydroxy-16β- methyl-3-oxoandrosta-1,4-diene-17β-carboxylate.

Inventors:
BODOR, Nicholas, S. (10225 Collins Avenue, Units 1002-1004Bal Harbour, FL, 33154, US)
Application Number:
US2018/037366
Publication Date:
June 13, 2019
Filing Date:
June 13, 2018
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
BODOR LABORATORIES, INC. (4400 Biscayne Boulevard, Suite 980Miami, FL, 33137, US)
International Classes:
A61K31/56; A61K31/569; A61P29/00; C07J3/00
Attorney, Agent or Firm:
BRUEHS, Martin A. (Dentons US LLP, 233 South Wacker DriveSuite 590, Chicago Illinois, 60606, US)
Download PDF: