Title:
POWDER PREPARATION FOR NASAL ADMINISTRATION
Document Type and Number:
WIPO Patent Application WO/2019/103108
Kind Code:
A1
Abstract:
The purpose of the present invention is to prepare a powder preparation for nasal administration that includes, as an active ingredient, a particulate steroid hormone having an average particle size of 50–300μm. The powder preparation for nasal administration may further include a water-soluble polymer (in particular, a water-soluble polysaccharide such as cellulose comprising a hydroxyalkyl group). The particulate steroid hormone may be formed from testosterone and/or a derivative thereof. The water-soluble polymer may be particulate. The proportion of the water-soluble polymer may be around 1–50 parts by weight with respect to 1 part by weight of the particulate steroid hormone. This powder preparation for nasal administration may be configured such that the Cmax of the steroid hormone component can be adjusted to be 15ng/ml or less. The powder preparation for nasal administration enables the concentration of a steroid hormone such as testosterone in the blood to be constrained to a specific range over a long period of time.
Inventors:
MINATO KOICHI (JP)
FUJISAWA TOMOYA (JP)
SHIMIZU KENJI (JP)
SAITO TAKAHISA (JP)
YAJIMA HIROYA (JP)
SASAKI KAZUHIRO (JP)
FUJISAWA TOMOYA (JP)
SHIMIZU KENJI (JP)
SAITO TAKAHISA (JP)
YAJIMA HIROYA (JP)
SASAKI KAZUHIRO (JP)
Application Number:
PCT/JP2018/043233
Publication Date:
May 31, 2019
Filing Date:
November 22, 2018
Export Citation:
Assignee:
ASKA PHARM CO LTD (JP)
International Classes:
A61K31/568; A61K9/14; A61K47/38; A61P15/12
Foreign References:
| JP2007001926A | 2007-01-11 | |||
| JPH09291026A | 1997-11-11 | |||
| JP2007530446A | 2007-11-01 | |||
| JPS6242888B2 | 1987-09-10 | |||
| JP2016000718A | 2016-01-07 | |||
| JPH1059841A | 1998-03-03 | |||
| JP2012526726A | 2012-11-01 | |||
| JPH11130659A | 1999-05-18 | |||
| JP2012526726A | 2012-11-01 | |||
| JPH09291025A | 1997-11-11 |
Other References:
ASCENTIIS, ALESSIA DE ET AL.: "Delivery of Nasal Powders of beta-Cyclodextrin by Insufflation", PHARMACEUTICAL RESEARCH, vol. 13, no. 5, 1996, pages 734 - 738, XP055617284, ISSN: 1573-904X
JAPANESE JOURNAL OF UROLOGY, vol. 95, 2004, pages 751 - 760
See also references of EP 3718550A4
JAPANESE JOURNAL OF UROLOGY, vol. 95, 2004, pages 751 - 760
See also references of EP 3718550A4
Attorney, Agent or Firm:
KUWATA Mitsuo et al. (JP)
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