Title:
A PRACTICAL, COST-EFFECTIVE SYNTHESIS OF CHLOROMETHYLATED 1,4-BENZOQUINONES
Document Type and Number:
WIPO Patent Application WO2006032425
Kind Code:
A3
Abstract:
The present invention relates to a practical and cost-effective method for the synthesis of 5-chloromethylated 2,3-dialkoxy-6-alkyl-1,4-benzoquinones by direct chloromethylation of the corresponding 2,3-dialkoxy-6-alkyl-1,4-benzoquinones. The invention further relates to a method for the preparation of 5-chloromethylated 2,3-dialkoxy-6-alkyl-1,4-benzoquinones starting from a 3,4,5-trialkoxy-1-alkyl-benzene. The invention also relates to a method for the production of Coenzymes Qn, especially coenzyme Q10.
Inventors:
BERL VOLKER (DE)
WETTERICH FRANK (DE)
ERNST HANSGEORG (DE)
SCHEIN KARIN (DE)
WETTERICH FRANK (DE)
ERNST HANSGEORG (DE)
SCHEIN KARIN (DE)
Application Number:
PCT/EP2005/010057
Publication Date:
April 27, 2006
Filing Date:
September 17, 2005
Export Citation:
Assignee:
BASF AG (DE)
BERL VOLKER (DE)
WETTERICH FRANK (DE)
ERNST HANSGEORG (DE)
SCHEIN KARIN (DE)
BERL VOLKER (DE)
WETTERICH FRANK (DE)
ERNST HANSGEORG (DE)
SCHEIN KARIN (DE)
International Classes:
C07C50/28; C07C17/32
Other References:
LIPSHUTZ, BRUCE H. ET AL: "A Convergent Approach to Coenzyme Q", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY , 121(50), 11664-11673 CODEN: JACSAT; ISSN: 0002-7863, 1999, XP002325073
GIRAUD, ANNE ET AL: "Radical reactions leading to substituted coumarins", TETRAHEDRON LETTERS , 40(23), 4321-4322 CODEN: TELEAY; ISSN: 0040-4039, 1999, XP002325074
LIPSHUTZ, BRUCE H. ET AL: "An expeditious route to CoQn, vitamins K1 and K2, and related allylated para-quinones utilizing Ni(0) catalysis", TETRAHEDRON , 54(7), 1241-1253 CODEN: TETRAB; ISSN: 0040-4020, 1998, XP002325075
KEINAN E. ET AL.: "Total Synthesis of Linear Polyprenoids.2. Improved Preparation of the Aromatic Nucleus of Ubiquinone", J. ORG. CHEM, vol. 52, no. 17, 1987, pages 3872 - 3875, XP002370847
GIRAUD, ANNE ET AL: "Radical reactions leading to substituted coumarins", TETRAHEDRON LETTERS , 40(23), 4321-4322 CODEN: TELEAY; ISSN: 0040-4039, 1999, XP002325074
LIPSHUTZ, BRUCE H. ET AL: "An expeditious route to CoQn, vitamins K1 and K2, and related allylated para-quinones utilizing Ni(0) catalysis", TETRAHEDRON , 54(7), 1241-1253 CODEN: TETRAB; ISSN: 0040-4020, 1998, XP002325075
KEINAN E. ET AL.: "Total Synthesis of Linear Polyprenoids.2. Improved Preparation of the Aromatic Nucleus of Ubiquinone", J. ORG. CHEM, vol. 52, no. 17, 1987, pages 3872 - 3875, XP002370847
Download PDF:
Previous Patent: WATER-DISPERSIBLE HIGHLY FUNCTIONAL POLYISOCYANATES
Next Patent: RECOMBINATION CASSETTES AND METHODS FOR SEQUENCE EXCISION IN PLANTS
Next Patent: RECOMBINATION CASSETTES AND METHODS FOR SEQUENCE EXCISION IN PLANTS