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Title:
PRACTICAL METHOD FOR MANUFACTURING 3,3-DIFLUORO-2-HYDROXYPROPIONIC ACID
Document Type and Number:
WIPO Patent Application WO/2016/158365
Kind Code:
A1
Abstract:
Provided is a practical method for manufacturing 3,3-difluoro-2-hydroxypropionic acid, which is important as an intermediate for medical and agricultural chemicals. By reacting a 4,4-difluoro-3-oxobutanoic acid ester with chlorine (Cl2), a 4,4-difluoro-2,2-dichloro-3-oxobutanoic acid ester is obtained. By then reacting with an acid, 3,3-difluoro-1,1-dichloro-2-propanone is obtained. Finally, by reacting with a basic aqueous solution, 3,3-difluoro-2-hydroxypropionic acid can be manufactured.

Inventors:
YAMAZAKI, Takako (LIMITED 17-5, Nakadai 2-chome, Kawagoe-sh, Saitama 59, 〒3501159, JP)
OKAMOTO, Ryuichi (LIMITED 17-5, Nakadai 2-chome, Kawagoe-sh, Saitama 59, 〒3501159, JP)
ISHII, Akihiro (LIMITED 17-5, Nakadai 2-chome, Kawagoe-sh, Saitama 59, 〒3501159, JP)
Application Number:
JP2016/058056
Publication Date:
October 06, 2016
Filing Date:
March 15, 2016
Export Citation:
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Assignee:
CENTRAL GLASS COMPANY, LIMITED (5253, Oaza Okiube Ube-sh, Yamaguchi 01, 〒7550001, JP)
International Classes:
C07C51/00; C07C59/115; C07C69/716
Foreign References:
JP2004018503A2004-01-22
JPH09227440A1997-09-02
CN101429083A2009-05-13
JP2015204762A2015-11-19
JP2007039384A2007-02-15
JPS53130620A1978-11-14
CN103570533A2014-02-12
JP2008120802A2008-05-29
JPS61191648A1986-08-26
Other References:
TAKAHASHI S. ET AL.: "Isomorphic supramolecular structures via one-dimensional hydrogen bonding motifs in crystals of chiral difluorolactates, trichlorolactates and trifluorolactates", CRYSTENGCOMM, vol. 8, 2006, pages 320 - 326, XP055316888
Attorney, Agent or Firm:
KOBAYASHI, Hiromichi et al. (Ekisaikai Bldg. 1-29, Akashi-cho, Chuo-k, Tokyo 44, 〒1040044, JP)
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