Title:
PRAME BINDING MOLECULES AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/186158
Kind Code:
A3
Abstract:
The present invention provides various PRAME binding molecules (including antibodies, antibody fragments, chimeric antigen receptors, and the like), compositions and cells comprising such PRAME binding molecules, and methods of using such PRAME binding molecules, compositions and cells, for example in the detection and/or monitoring of PRAME-positive tumors.
Inventors:
ULMERT HANS (US)
O'REILLY RICHARD (US)
SJOSTROM KJELL (SE)
O'REILLY RICHARD (US)
SJOSTROM KJELL (SE)
Application Number:
PCT/US2020/022628
Publication Date:
October 22, 2020
Filing Date:
March 13, 2020
Export Citation:
Assignee:
ULMERT HANS DAVID STAFFAN (US)
OREILLY RICHARD JOHN (US)
SJOSTROM KJELL TORSTEN (SE)
OREILLY RICHARD JOHN (US)
SJOSTROM KJELL TORSTEN (SE)
International Classes:
A61P35/00; A61K39/395; C07K16/28; C07K16/30
Foreign References:
| US20100135996A1 | 2010-06-03 | |||
| US20170166634A1 | 2017-06-15 | |||
| US20180148503A1 | 2018-05-31 |
Other References:
DMITRY PANKOV, LUDVIG SJÖSTRÖM, TEJA KALIDINDI , SANG-GYU LEE, KJELL SJÖSTRÖM , RUI GARDNER , MICHAEL R MCDEVITT, RICHARD O'REILL: "In vivo immuno-targeting of an extracellular epitope uf membrane bound preferentially expressed antigen in melanoma (PRAME", ONCOTARGET, vol. 8, no. 39, 26 July 2017 (2017-07-26), pages 65917 - 65931, XP055749204
AARON CHANG, TAO DAO, PHD, ANDREW SCOTT, LEONID DUBROVSKY, MD, CHENG LIU, PHD, DAVID A. SCHEINBERG, MD PHD: "A Therapeutic TCR Mimic Monoclonal Antibody for Intracellular PRAME Protein in Leukemias", BLOOD, vol. 126, no. 23, 3 December 2015 (2015-12-03), pages 2527, XP055754957
AARON CHANG, TAO DAO, PHD, ANDREW SCOTT, LEONID DUBROVSKY, MD, CHENG LIU, PHD, DAVID A. SCHEINBERG, MD PHD: "A Therapeutic TCR Mimic Monoclonal Antibody for Intracellular PRAME Protein in Leukemias", BLOOD, vol. 126, no. 23, 3 December 2015 (2015-12-03), pages 2527, XP055754957
Attorney, Agent or Firm:
GRIMES, Julia, Anne (US)
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