PREDICTING GRAFT REJECTION - BETH ISRAEL HOSPITAL

Title:

PREDICTING GRAFT REJECTION

Document Type and Number:

WIPO Patent Application WO2004074815

Kind Code:

A3

Abstract:

The present invention features prognostic methods useful in assessing patients who have received a transplant and reagents, optionally packaged as kits or organized as arrays, that can be used to carry out those methods. The inventions are based, in part, on our analysis of gene expression in renal allografts and clinical parameters, such as the age of the donor. The clinical parameters include one or more variables associated with the recipient (e.g., the recipient's age and/or race); one or more variables associated with the graft (e.g., whether the graft is obtained from a living donor or a cadaver and the ischemic time); and variables associated with the donor (e.g., the donor's age and/or race). The genes that can be assessed include those encoding agents that mediate inflammation, immune activation, and cell death (we may refer to these genes below as "inflammatory", "immune" or "cytoprotective"). Surprisingly, we found that the levels of gene expression could predict the occurrence of DGF, AR, and the quality of later graft function even when analyzed shortly after the transplant was performed (e.g., shortly after vascular anastomosis and tissue reperfusion). We also found that clinical parameters available at the time of transplantation correlate with decreased graft health and can be considered in combination with gene expression to evaluate a patient's risk for an adverse outcome.

Inventors:

STROM TERRY B
LIBERMANN TOWIA (US)
SCHACHTER ASHER (US)

Application Number:

PCT/US2004/004839

Publication Date:

January 13, 2005

Filing Date:

February 17, 2004

Export Citation:

Click for automatic bibliography generation Help

Assignee:

BETH ISRAEL HOSPITAL (US)
STROM TERRY B
LIBERMANN TOWIA (US)
SCHACHTER ASHER (US)

International Classes:

C07H21/04; C12P19/34; C12Q1/68; G01N; (IPC1-7): C12Q1/68; C07H21/04; C12P19/34

Domestic Patent References:

WO1999055859A2

1999-11-04

Foreign References:

US20020142461A1	2002-10-03
US6355775B1	2002-03-12
US20020151009A1	2002-10-17

Other References: