Title:
PREDICTION AND/OR DETERMINATION MARKER FOR EFFECTIVENESS OF TREATMENT WITH DRUG CONTAINING PD-1 SIGNAL INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2020/149026
Kind Code:
A8
Abstract:
The present invention provides a testing method comprising predicting and/or determining the effectiveness of treatment with a drug containing a PD-1 signal inhibitor using the following (i) and/or (ii) as an index. (i) A metabolite in serum and/or plasma associated with a microbiome, energy metabolism, and redox. (ii) At least one cellular marker in peripheral blood selected from the group consisting of the frequency of CD4+ T cells among peripheral blood mononuclear cells (PBMC), the frequency of CD8+ T cell populations, the ratio of the mitochondrial reactive oxygen expression amount of CD8+ T cells to the mitochondrial reactive oxygen expression amount of CD4+ T cells, and the expression of PGC-1α and PGC-1β of CD8+ T cells.
Inventors:
HONJO TASUKU (JP)
CHAMOTO KENJI (JP)
MATSUDA FUMIHIKO (JP)
CHAMOTO KENJI (JP)
MATSUDA FUMIHIKO (JP)
Application Number:
PCT/JP2019/046582
Publication Date:
September 17, 2020
Filing Date:
November 28, 2019
Export Citation:
Assignee:
UNIV KYOTO (JP)
International Classes:
A61K39/395; A61K45/00; A61P31/00; A61P35/00; A61P43/00; C12Q1/02; G01N33/15; G01N33/50; G01N33/574; G01N33/68
Attorney, Agent or Firm:
MAYAMA, Setsuko et al. (JP)
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