Title:
PREDICTION OF OUTCOME IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Document Type and Number:
WIPO Patent Application WO/2013/131621
Kind Code:
A8
Abstract:
The present invention relates to a method for the prognosis and/or risk assessment and/or monitoring of therapy and/or management of patients with COPD the method comprising the steps of: i) providing a sample of a bodily fluid from said patient, ii) determining in said sample the level of at least one biomarker, selected from the group consisting of pro-adrenomedullin (proADM), pronatriuretic peptide, pro-Vasopressin (proAVP) and Pro-calcitonin (PCT) or fragments thereof of at least 12 amino acids in length, iii) determining one, two or three of the BODE-index parameters body-mass index (BMI, parameter B), degree of airflow obstruction (FEV1, parameter O), dyspnea (parameter D) and exercise capacity (parameter E), iv) correlating said level of said at least one biomarker determined in step ii), in combination with said one, two or three BODE-index parameters determined in step iii) to the prognosis and/or risk assessment and/or monitoring of therapy and/or management of patients with COPD.
Inventors:
GIERSDORF SVEN (DE)
TAMM MICHAEL (CH)
STOLZ DAIANA (CH)
TAMM MICHAEL (CH)
STOLZ DAIANA (CH)
Application Number:
PCT/EP2013/000558
Publication Date:
June 12, 2014
Filing Date:
February 26, 2013
Export Citation:
Assignee:
BRAHMS GMBH (DE)
International Classes:
G01N33/68; G01N33/74
Attorney, Agent or Firm:
TOMERIUS, Isabel et al. (Rosa-Bavarese-Str. 5, München, DE)
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