PREDICTION OF PROGNOSIS OF LIVER DISEASE ASSOCIATED WITH HEPATITIS C VIRUS INFECTION

WIPO Patent Application WO/2006/112482

A1

Disclosed is a method for the prediction of progress of a liver disease associated with HCV infection, the method comprising determining the antibody titer of an antibody against a peptide comprising an amino acid sequence composed of contiguous 8 or more amino acid residues containing amino acid Gly 32 of a hepatitis C virus core protein in the blood of a subject. Further, the antibody titer against NS5A-2132 peptide of hepatitis C virus and the antibody titer against C33 or C35 peptide of a hepatitis C virus core protein are also determined. Based on the combination of these results, it becomes possible to predict the prognosis with higher reliability. Also disclosed is a kit for use in the prediction of the progress of a liver disease associated with hepatitis C virus infection, the kit comprising a peptide which can be recognized by an anti-HCV antibody capable of binding to a peptide comprising an amino acid sequence composed of contiguous 8 or more amino acid residues containing amino acid Gly 32 of a hepatitis C virus core protein.

ITOH KYOGO (JP)
SATA MICHIO (JP)
YUTANI SHIGERU (JP)
KOMATSU NOBUKAZU (JP)
YAMADA AKIRA (JP)

PCT/JP2006/308233

October 26, 2006

April 19, 2006

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UNIV KURUME (JP)
ITOH KYOGO (JP)
SATA MICHIO (JP)
YUTANI SHIGERU (JP)
KOMATSU NOBUKAZU (JP)
YAMADA AKIRA (JP)

G01N33/576; G01N33/574

WO2005028503A1

2005-03-31

JPH06247997A	1994-09-06
JPH04121193A	1992-04-22

Ohno, Seiji (Kasumigaseki Building 36F 2-, Kasumigaseki 3-chome Chiyoda-ku Tokyo 36, JP)

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