Title:
PREPARATION OF 3,4-DIHYDRO-1,4-BENZOXAZEPIN-5(2H)-ONE DERIVATIVES BY CYCLISATION OF 2-(AM I NO ETHYLOXY) BENZOIC ACID DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2015/123519
Kind Code:
A3
Abstract:
The present disclosure provides processes for the preparation of a compound of formula: which is a selective late sodium current inhibitor. The disclosure also provides compounds that are synthetic intermediates.
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Inventors:
CHIU ANNA (US)
FENG YANSHU (CN)
GAO HANRONG (CN)
KERSCHEN JAMES A (US)
REICHWEIN JOHN (US)
SARMA KESHAB (US)
THOMPSON ANDREW S (US)
ZHAO XINJUN (CL)
FENG YANSHU (CN)
GAO HANRONG (CN)
KERSCHEN JAMES A (US)
REICHWEIN JOHN (US)
SARMA KESHAB (US)
THOMPSON ANDREW S (US)
ZHAO XINJUN (CL)
Application Number:
PCT/US2015/015814
Publication Date:
October 22, 2015
Filing Date:
February 13, 2015
Export Citation:
Assignee:
GILEAD SCIENCES INC (US)
International Classes:
C07D267/14
Domestic Patent References:
| WO2013112932A1 | 2013-08-01 |
Foreign References:
| US20100174065A1 | 2010-07-08 |
Other References:
BRADY, RYAN M. ET AL: "Synthesis of conformationally constrained benzoylureas as BH3-mimetics", ORGANIC AND BIOMOLECULAR CHEMISTRY, vol. 10, no. 27, 15 May 2012 (2012-05-15), pages 5230 - 5237, XP002738888, DOI: 10.1039/C2OB25618E
KAMEI K ET AL: "Synthesis, SAR studies, and evaluation of 1,4-benzoxazepine derivatives as selective 5-HT1A receptor agonists with neuroprotective effect: Discovery of Piclozotan", BIOORGANIC & MEDICINAL CHEMISTRY, PERGAMON, GB, vol. 14, no. 6, 15 March 2006 (2006-03-15), pages 1978 - 1992, XP027992458, ISSN: 0968-0896, [retrieved on 20060315], DOI: 10.1016/j.bmc.2005.10.046
BARSKY L I ET AL: "Hypoglycemic Cyclic Amidines", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 14, no. 1, 1 January 1971 (1971-01-01), pages 40 - 44, XP002682484, ISSN: 0022-2623, DOI: 10.1021/jm00283a011
KAMEI K ET AL: "Synthesis, SAR studies, and evaluation of 1,4-benzoxazepine derivatives as selective 5-HT1A receptor agonists with neuroprotective effect: Discovery of Piclozotan", BIOORGANIC & MEDICINAL CHEMISTRY, PERGAMON, GB, vol. 14, no. 6, 15 March 2006 (2006-03-15), pages 1978 - 1992, XP027992458, ISSN: 0968-0896, [retrieved on 20060315], DOI: 10.1016/j.bmc.2005.10.046
BARSKY L I ET AL: "Hypoglycemic Cyclic Amidines", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 14, no. 1, 1 January 1971 (1971-01-01), pages 40 - 44, XP002682484, ISSN: 0022-2623, DOI: 10.1021/jm00283a011
Attorney, Agent or Firm:
GINAH, Francis, O. et al. (Inc.333 Lakeside Driv, Foster City CA, US)
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