Title:
PREPARATION OF ALKYL-SUBSTITUTED 2-DEOXY-2-FLUORO-D-RIBOFURANOSYL PYRIMIDINES AND PURINES AND THEIR DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2006/012440
Kind Code:
A8
Abstract:
The present invention provides (i) a process for preparing a 2-deoxy-2-fluoro-2-methyl-D-ribonolactone derivative, (ii) conversion of the lactone to nucleosides with potent anti-HCV activity, and their analogues, and (iii) a method to prepare the anti-HCV nucleosides containing the 2-deoxy-2-fluoro-2-C-methyl-β-D-ribofuranosyl nucleosides from a preformed, preferably naturally-occurring, nucleoside.
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Inventors:
WANG PEIYUAN (US)
STEC WOJCIECH (PL)
CHUN BYOUNG-KWON (US)
SHI JUNXING (US)
DU JINFA (US)
STEC WOJCIECH (PL)
CHUN BYOUNG-KWON (US)
SHI JUNXING (US)
DU JINFA (US)
Application Number:
PCT/US2005/025916
Publication Date:
June 16, 2011
Filing Date:
July 21, 2005
Export Citation:
Assignee:
PHARMASSET INC (US)
WANG PEIYUAN (US)
STEC WOJCIECH (PL)
CHUN BYOUNG-KWON (US)
SHI JUNXING (US)
DU JINFA (US)
WANG PEIYUAN (US)
STEC WOJCIECH (PL)
CHUN BYOUNG-KWON (US)
SHI JUNXING (US)
DU JINFA (US)
International Classes:
C07H19/00; C07H5/04; C07H5/06; C07H21/00; C08B37/00
Attorney, Agent or Firm:
SCHMALTZ, David, G. (P.O. Box 2903Minneapolis, MN, US)
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