Title:
PREPARATION AND APPLICATION OF SHP2 PHOSPHATASE INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2022/237676
Kind Code:
A1
Abstract:
Disclosed in the present invention are a SHP2 phosphatase inhibitor and an application thereof. Specifically, the present invention relates to a compound as represented by formula (I), a preparation method therefor, a pharmaceutical composition containing the compound, and an application of the compound as a protein tyrosine phosphatase SHP2 inhibitor in a medication for treatment of leukemia, neuroblastoma, melanoma, acute myeloid leukemia, breast cancer, esophageal cancer, lung cancer, colon cancer, head cancer, pancreatic cancer, head and neck squamous cell carcinoma, gastric cancer, liver cancer, anaplastic large cell lymphoma, and glioblastoma, wherein definitions of the substituents in the formula (I) are the same as those in the description.
Inventors:
LIANG YONGHONG (CN)
XU ZHIYONG (CN)
ZENG ZHAOSEN (CN)
YAN WENGUANG (CN)
XIONG FANGJUN (CN)
XU ZHIYONG (CN)
ZENG ZHAOSEN (CN)
YAN WENGUANG (CN)
XIONG FANGJUN (CN)
Application Number:
PCT/CN2022/091425
Publication Date:
November 17, 2022
Filing Date:
May 07, 2022
Export Citation:
Assignee:
YA THERAPEUTICS INC (CN)
International Classes:
C07D491/107; A61K31/506; A61K31/53; A61P35/00
Domestic Patent References:
| WO2020081848A1 | 2020-04-23 | |||
| WO2020201991A1 | 2020-10-08 | |||
| WO2020063760A1 | 2020-04-02 |
Foreign References:
| CN112166110A | 2021-01-01 | |||
| US20040180925A1 | 2004-09-16 | |||
| CN110143949A | 2019-08-20 | |||
| CN105899493A | 2016-08-24 | |||
| CN111153899A | 2020-05-15 |
Attorney, Agent or Firm:
SHENZHEN ZHONGZHILIXIN INTELLECTUAL PROPERTY AGENT CO., LTD. (CN)
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