Title:
PREPARATION OF BICYCLO[2.2.2]OCTAN-2-ONE COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/2012/052939
Kind Code:
A3
Abstract:
The present invention relates to a new process for the preparation of 6-hydroxy-5- arylbicyclo[2.2.2]octan-2-one compounds of the formula (II); which may subsequently be further transformed to compounds of the formula (I): Formula (I) Formula (II). The present invention further relates to novel compounds as such, which compounds are useful intermediates in the above process.
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Inventors:
ABELE STEFAN (CH)
FUNEL JACQUES-ALEXIS (FR)
FUNEL JACQUES-ALEXIS (FR)
Application Number:
PCT/IB2011/054660
Publication Date:
June 21, 2012
Filing Date:
October 19, 2011
Export Citation:
Assignee:
ACTELION PHARMACEUTICALS LTD (CH)
ABELE STEFAN (CH)
FUNEL JACQUES-ALEXIS (FR)
ABELE STEFAN (CH)
FUNEL JACQUES-ALEXIS (FR)
International Classes:
C07C45/51; C07C45/61; C07C45/86; C07C47/198; C07C309/66; C07D317/72
Other References:
MARCO BELLA ET AL: "Synergic asymmetric organocatalysis (SAOc) of Cinchona alkaloids and secondary amines in the synthesis of bicyclo[2.2.2]octan-2-ones", CHEMICAL COMMUNICATIONS, no. 5, 1 January 2009 (2009-01-01), pages 597, XP055012788, ISSN: 1359-7345, DOI: 10.1039/b816550e
PHILIP SCHMOLDT ET AL: "A Versatile Synthesis of Bicyclo[2.2.2]octan-2-oneDerivatives", SYNTHESIS, vol. 2003, no. 07, 1 January 2003 (2003-01-01), pages 1071 - 1078, XP055025092, ISSN: 0039-7881, DOI: 10.1055/s-2003-39174
CARINC.C. JOHANSSON ET AL: "Metal-Catalyzed [alpha]-Arylation of Carbonyl and Related Molecules: Novel Trends in CC Bond Formation by CH Bond Functionalization", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 49, no. 4, 18 January 2010 (2010-01-18), pages 676 - 707, XP055025203, ISSN: 1433-7851, DOI: 10.1002/anie.200903424
PHILIP SCHMOLDT ET AL: "A Versatile Synthesis of Bicyclo[2.2.2]octan-2-oneDerivatives", SYNTHESIS, vol. 2003, no. 07, 1 January 2003 (2003-01-01), pages 1071 - 1078, XP055025092, ISSN: 0039-7881, DOI: 10.1055/s-2003-39174
CARINC.C. JOHANSSON ET AL: "Metal-Catalyzed [alpha]-Arylation of Carbonyl and Related Molecules: Novel Trends in CC Bond Formation by CH Bond Functionalization", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 49, no. 4, 18 January 2010 (2010-01-18), pages 676 - 707, XP055025203, ISSN: 1433-7851, DOI: 10.1002/anie.200903424
Attorney, Agent or Firm:
VELKER, Jörg (Gewerbestrasse 16, Allschwil, CH)
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