Title:
PREPARATION FOR CHITOSAN AND PROPYLENE GLYCOL ALGINATE BLENDED MICROCAPSULE AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/232823
Kind Code:
A1
Abstract:
Provided are preparation for a chitosan and propylene glycol alginate blended microcapsule and an application thereof, pertaining to the field of preparation and application of microcapsules. The preparation comprises dissolving chitosan with an acetic acid solution having a mass percentage concentration of 0.5-5%, dissolving propylene glycol alginate with water, then mixing the two solutions, introducing a 2-8% aqueous solution of NaOH in a high-voltage electrostatic field to form wet blended microcapsules, and then washing and drying the wet blended microcapsules to obtain dry blended microcapsules. The prepared chitosan and propylene glycol alginate blended microcapsule can be used as an embolic material for vascular embolization, where the embolic material is injected or fed into a target blood vessel through a catheter to occlude the blood vessel at a target position. Good expansion properties of the embolic material can avoid the migration of microcapsules in blood vessels, and the stable structure thereof can stabilize embolisms. Further, the blended microcapsule is applicable to sustained-release drugs as a carrier for a sustained-release drug, achieving the effect of desirable sustained release of the drug by combining the blended microcapsule with the drug.
Inventors:
ZHANG DEMENG (CN)
ZHANG MENGXUE (CN)
DENG YUNLONG (CN)
SHI SHAOJUAN (CN)
QIN YIMIN (CN)
ZHANG MENGXUE (CN)
DENG YUNLONG (CN)
SHI SHAOJUAN (CN)
QIN YIMIN (CN)
Application Number:
PCT/CN2018/092431
Publication Date:
December 12, 2019
Filing Date:
June 22, 2018
Export Citation:
Assignee:
QINGDAO BRIGHT MOON BIOMEDICAL MAT CO LTD (CN)
International Classes:
B01J13/02; A61K9/50; A61K9/52; A61K47/36; A61L24/00; A61L24/04; B01J13/04
Foreign References:
| CN103012859A | 2013-04-03 | |||
| CN1879607A | 2006-12-20 | |||
| CN103627010A | 2014-03-12 |
Other References:
30 September 2013 (2013-09-30)
Attorney, Agent or Firm:
QINGDAO ZHIDILINGCHUANG PATENT AGENCY CO., LTD (CN)
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