PREPARATION OF KETONE AMIDES

Title:

PREPARATION OF KETONE AMIDES

Document Type and Number:

WIPO Patent Application WO2006074264

Kind Code:

A3

Abstract:

The present invention discloses a novel process to prepare ketone amides, which are useful intermediates for the preparation of antagonists of CCR5 receptor and therefore useful for the treatment of HIV virus infected mammals. It specifically discloses a novel process to synthesize 1 -(2,4-dimethylpyrimidine-5-carbonyl)-4-piperidone, 1 -[(2,4-dimethyl-3- pyridinyl)carbonyl]-4-piperidone and related compounds. A salient feature of the invention is the use of a three-phase reaction medium with an organic phase and a buffer salt slurry. (formule I)

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Inventors:

KUO SHEN-CHUN (US)
TSAI DAVID JIEH-SHYH (US)
LIAO HONGBIAO (US)

Application Number:

PCT/US2006/000251

Publication Date:

November 02, 2006

Filing Date:

January 05, 2006

Export Citation:

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Assignee:

SCHERING CORP (US)
KUO SHEN-CHUN (US)
TSAI DAVID JIEH-SHYH (US)
LIAO HONGBIAO (US)

International Classes:

C07D401/06

Domestic Patent References:

WO2003084950A1

2003-10-16

Foreign References:

US20030069252A1	2003-04-10
US20030004185A1	2003-01-02

Other References:

G. XU, A. KANNAN, T. L. HARTMAN, H. WARGO, K. WATSON, J. A. TURPIN, R. W. BUCKHEIT, A. A. JOHNSON, Y. POMMIER, M. CUSHMAN: "Synthesis of Substituted Diarylmethylenepiperidines (DAMPs), a Novel Class of Anti-HIV Agents", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 10, 2002, pages 2807 - 2816, XP002381120

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