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Title:
PREPARATION OF M(CO)3-COMPLEXES BY SOLID PHASE TECHNIQUES VIA METAL ASSISTED CLEAVAGE FROM THE SOLID SUPPORT
Document Type and Number:
WIPO Patent Application WO2004022105
Kind Code:
A3
Abstract:
The present invention relates to a process for generating a water soluble metal complexed agent, comprising contacting a solid phase bound organic conjugate represented by the formula I with [M(H2O)3(CO)3], under suitable conditions to cause the formation of a coordinate bond between [M(H2O)3(CO)3] and the tertiary amine nitrogen atom of the solid phase bound organic conjugate and thereby the release of the metal complexed agent thus formed from the support. The invention further relates to the conjugate of formula (I) and to a kit for performing the process.

Inventors:
ALBERTO ROGER (CH)
MUNDWILER STEFAN (CH)
Application Number:
US0327665W
Publication Date:
April 22, 2004
Filing Date:
September 02, 2003
Export Citation:
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Assignee:
MALLINCKRODT INC.
ALBERTO, ROGER
MUNDWILER, STEFAN
International Classes:
A61K47/48; A61K51/04; A61K51/12; C07F1/08; C07F13/00; C07F15/00; (IPC1-7): A61K51/04; A61K51/12; C07F1/08; C07F13/00; C07F15/00
Domestic Patent References:
WO2001089586A22001-11-29
WO2001000637A12001-01-04
WO1998048848A11998-11-05
WO2001025243A12001-04-12
Foreign References:
EP1013642A22000-06-28
US5789555A1998-08-04
Other References:
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