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Patent Searching and Data


Title:
PREPARATION METHOD FOR AZACITIDINE INJECTION
Document Type and Number:
WIPO Patent Application WO/2017/162103
Kind Code:
A1
Abstract:
Disclosed is a preparation method for an azacitidine injection, wherein each azacitidine injection comprises 100 mg of azacitidine and 100 mg of mannitol. The preparation method comprises the steps of measuring 80% water for injection, and controlling the temperature at 2-6°C; adding mannitol, stirring until completely dissolved, and controlling the temperature at 2-6°C; adding azacitidine, stirring until completely dissolved, and controlling the temperature at 2-6°C; sub-packaging into 23 ml/bottle after filtration; freeze-drying according to a preset temperature; and tamponing, capping and packaging after nitrogen filling. The preparation method has the advantages of a simple process, low energy consumption, high production efficiency and stable product quality.

Inventors:
SHI, Xiangjie (Xunqiao, Linhai, Zhejiang 4, 317024, CN)
LIU, Jiening (Xunqiao, Linhai, Zhejiang 4, 317024, CN)
WANG, Xinshi (Xunqiao, Linhai, Zhejiang 4, 317024, CN)
HU, Libin (Xunqiao, Linhai, Zhejiang 4, 317024, CN)
CHEN, Hao (Xunqiao, Linhai, Zhejiang 4, 317024, CN)
WANG, Zhiyun (Xunqiao, Linhai, Zhejiang 4, 317024, CN)
Application Number:
CN2017/077026
Publication Date:
September 28, 2017
Filing Date:
March 17, 2017
Export Citation:
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Assignee:
ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD (Xunqiao, Linhai, Zhejiang 4, 317024, CN)
International Classes:
A61K9/19; A61K31/706; A61P7/00; A61P7/06; A61P35/02; F26B5/06
Foreign References:
CN103338753A2013-10-02
CN101632643A2010-01-27
US20110042247A12011-02-24
CN105769775A2016-07-20
Attorney, Agent or Firm:
PATENTSINO IP FIRM (Suite 413, Shang Fang BuildingNo.27 North Third Ring Road Middl, Xicheng District Beijing 9, 100029, CN)
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