Title:
PREPARATION METHOD OF DROSPIRENONE
Document Type and Number:
WIPO Patent Application WO/2011/113196
Kind Code:
A1
Abstract:
Preparation method of drospirenone is disclosed, which uses 3β,5-dihydroxy-6β,7β,15β,16β-dimethylene-5β-androster-17, 20-epoxy as the starting material and comprises the following steps: oxidizing the hydroxyl group at position 3, protecting the ketone group at position 3 with ketal, constructing carboxylic inner ester by condensation and deesterifying, then sulfonylating the hydroxyl group at position 5, and constructing 3-ketone-4-alkenyl by deprotecting ketal and desulfonylation at the same time in a reaction system comprising glacial acetic acid and sodium acetate to obtain drospirenone.
Inventors:
WANG, Jiazhen (No. 14 Industrial East Road, XianjvTaizhou, Zhejiang 0, 317300, CN)
Application Number:
CN2010/071074
Publication Date:
September 22, 2011
Filing Date:
March 16, 2010
Export Citation:
Assignee:
TAIZHOU TAIFA PHARMACEUTICALS CO., LTD (YANG, BinNo. 14 Industrial East Road, Xianj, Taizhou Zhejiang 0, 317300, CN)
台州太法药业有限公司 (中国浙江省台州市仙居县工业东路14号杨斌, Zhejiang 0, 317300, CN)
台州太法药业有限公司 (中国浙江省台州市仙居县工业东路14号杨斌, Zhejiang 0, 317300, CN)
International Classes:
C07J53/00
Attorney, Agent or Firm:
HANGZHOU TIANQIN INTELLECTUAL PROPERTY AGENCY CO., LTD (Room 501, Zhu-Pin-Jin-ZuoNo. 1 Jing-Zhou Road,Xihu District, Hangzhou, Zhejiang 3, 310013, CN)
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Claims: