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Title:
PREPARATION METHOD OF DROSPIRENONE
Document Type and Number:
WIPO Patent Application WO/2011/113196
Kind Code:
A1
Abstract:
Preparation method of drospirenone is disclosed, which uses 3β,5-dihydroxy-6β,7β,15β,16β-dimethylene-5β-androster-17, 20-epoxy as the starting material and comprises the following steps: oxidizing the hydroxyl group at position 3, protecting the ketone group at position 3 with ketal, constructing carboxylic inner ester by condensation and deesterifying, then sulfonylating the hydroxyl group at position 5, and constructing 3-ketone-4-alkenyl by deprotecting ketal and desulfonylation at the same time in a reaction system comprising glacial acetic acid and sodium acetate to obtain drospirenone.

Inventors:
WANG, Jiazhen (No. 14 Industrial East Road, XianjvTaizhou, Zhejiang 0, 317300, CN)
Application Number:
CN2010/071074
Publication Date:
September 22, 2011
Filing Date:
March 16, 2010
Export Citation:
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Assignee:
TAIZHOU TAIFA PHARMACEUTICALS CO., LTD (YANG, BinNo. 14 Industrial East Road, Xianj, Taizhou Zhejiang 0, 317300, CN)
台州太法药业有限公司 (中国浙江省台州市仙居县工业东路14号杨斌, Zhejiang 0, 317300, CN)
International Classes:
C07J53/00
Attorney, Agent or Firm:
HANGZHOU TIANQIN INTELLECTUAL PROPERTY AGENCY CO., LTD (Room 501, Zhu-Pin-Jin-ZuoNo. 1 Jing-Zhou Road,Xihu District, Hangzhou, Zhejiang 3, 310013, CN)
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Claims: