Title:
PREPARATION METHOD FOR EUTECTIC HYDRATE CRYSTAL FORM II OF AHU-377 AND DIOVAN TRISODIUM SALT
Document Type and Number:
WIPO Patent Application WO/2017/097085
Kind Code:
A1
Abstract:
Disclosed is a preparation method for a eutectic hydrate crystal form II of AHU-377 and diovan trisodium salt, comprising: firstly, obtaining a clear solution of an AHU-377 and diovan trisodium salt compound, a solvent of the clear solution consisting of an anti-solvent and an n-solvent of a target product crystal form II, and the boiling point of the n-solvent being lower than that of the anti-solvent; secondly, removing the n-solvent and water from a system by evaporation under closed conditions; and finally, selectively adding a seed crystal of the crystal form II, and additionally adding a mixture of water and a carrier solvent to perform stirring crystallization. The method in the present invention can prepare a crystal form II, and has a stable and controllable technological process. The prepared crystal form II product is high in chemical purity, crystal form purity and fluidity, the process can be amplified, and demands for large-scale production are met.
Inventors:
CHEN MINHUA (CN)
ZHANG YANFENG (CN)
ZHANG LIANG (CN)
ZHANG YANFENG (CN)
ZHANG LIANG (CN)
Application Number:
PCT/CN2016/105335
Publication Date:
June 15, 2017
Filing Date:
November 10, 2016
Export Citation:
Assignee:
CRYSTAL PHARMATECH CO LTD (CN)
International Classes:
C07D257/04; C07C231/24; C07C233/47
Foreign References:
| CN101098689A | 2008-01-02 | |||
| CN104860894A | 2015-08-26 | |||
| CN105037289A | 2015-11-11 |
Other References:
See also references of EP 3385256A4
Attorney, Agent or Firm:
SUZHOU CREATOR PATENT & TREADMARK AGENCY LTD. (CN)
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